Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help
A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help
AOPs Including This Stressor
This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help
|Antagonist binding to PPARα leading to body-weight loss||High|
A list of chemicals associated with a prototypical stressor. More help
List of the literature that was cited for this prototypical stressor. More help
Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT et al: Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR[alpha]. Nature 2002, 415(6873):813-817.