API

Stressor: 18

Title

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Dimethyl nitrosamine

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Dimethylnitrosamine DTXSID7021029 N-Nitrosodimethylamine 62-75-9 UMFJAHHVKNCGLG-UHFFFAOYSA-N UMFJAHHVKNCGLG-UHFFFAOYSA-N

AOP Evidence

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Protein Alkylation leading to Liver Fibrosis

see the chemical list under overall assessment




Event Evidence

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Alkylation, DNA

There is no evidence text for this event.



Alkylation, Protein

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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George et al. 2001,imethylnitrosamine-induced liver injury in rats: the early deposition of collagen, Toxicology; 2;156(2-3):129-38.

Godoy et al. 1980, Relationship Between Dimethylnitrosamine Metabolism or Activation and Its Ability To Induce Liver Necrosis in Rats, J Natl Cancer Inst, 64(3): 533-538.

Diaz Gomez et al, Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury,1981 Archives of Toxicology;47,3:159-168