API

Stressor: 18

Title

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Dimethyl nitrosamine

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Dimethylnitrosamine DTXSID7021029 N-Nitrosodimethylamine 62-75-9 UMFJAHHVKNCGLG-UHFFFAOYSA-N UMFJAHHVKNCGLG-UHFFFAOYSA-N

AOP Evidence

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Protein Alkylation leading to Liver Fibrosis

see the chemical list under overall assessment




Event Evidence

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Alkylation, DNA

There is no evidence text for this event.



Alkylation, Protein

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Instructions

To edit the “ Stressor Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Stressor Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Stressor Description”  section on the page.



Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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George et al. 2001,imethylnitrosamine-induced liver injury in rats: the early deposition of collagen, Toxicology; 2;156(2-3):129-38.

Godoy et al. 1980, Relationship Between Dimethylnitrosamine Metabolism or Activation and Its Ability To Induce Liver Necrosis in Rats, J Natl Cancer Inst, 64(3): 533-538.

Diaz Gomez et al, Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury,1981 Archives of Toxicology;47,3:159-168