Stressor: 18
Title
Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors.
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Dimethyl nitrosamine
Stressor Overview
A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP.
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AOPs Including This Stressor
This table is automatically generated and lists the AOPs associated with this prototypical stressor.
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| AOP Name | Evidence |
|---|---|
| Protein Alkylation leading to Liver Fibrosis | High |
Chemical Table
A list of chemicals associated with a prototypical stressor.
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| Preferred name | DTXID | Casrn | jchem_inchi_key | indigo_inchi_key | User term |
|---|---|---|---|---|---|
| N-Nitrosodimethylamine | DTXSID7021029 | 62-75-9 | UMFJAHHVKNCGLG-UHFFFAOYSA-N | UMFJAHHVKNCGLG-UHFFFAOYSA-N | Dimethylnitrosamine |
References
List of the literature that was cited for this prototypical stressor.
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George et al. 2001,imethylnitrosamine-induced liver injury in rats: the early deposition of collagen, Toxicology; 2;156(2-3):129-38.
Godoy et al. 1980, Relationship Between Dimethylnitrosamine Metabolism or Activation and Its Ability To Induce Liver Necrosis in Rats, J Natl Cancer Inst, 64(3): 533-538.
Diaz Gomez et al, Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury,1981 Archives of Toxicology;47,3:159-168