Stressor: 18

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE).  It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Dimethyl nitrosamine

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

Chemical Table

A list of chemicals associated with a prototypical stressor. More help
User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Dimethylnitrosamine DTXSID7021029 N-Nitrosodimethylamine 62-75-9 UMFJAHHVKNCGLG-UHFFFAOYSA-N UMFJAHHVKNCGLG-UHFFFAOYSA-N

References

List of the literature that was cited for this prototypical stressor. More help

George et al. 2001,imethylnitrosamine-induced liver injury in rats: the early deposition of collagen, Toxicology; 2;156(2-3):129-38.

Godoy et al. 1980, Relationship Between Dimethylnitrosamine Metabolism or Activation and Its Ability To Induce Liver Necrosis in Rats, J Natl Cancer Inst, 64(3): 533-538.

Diaz Gomez et al, Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury,1981 Archives of Toxicology;47,3:159-168