Stressor: 20


Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE).  It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Dioxin and dioxin-like compounds

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

Chemical Table

A list of chemicals associated with a prototypical stressor. More help
Preferred name DTXID Casrn jchem_inchi_key indigo_inchi_key User term
2,3,7,8-Tetrachlorodibenzo-p-dioxin DTXSID2021315 1746-01-6 HGUFODBRKLSHSI-UHFFFAOYSA-N HGUFODBRKLSHSI-UHFFFAOYSA-N 2,3,7,8-tetrachlorodibenzo[b,e][1,4]dioxin


List of the literature that was cited for this prototypical stressor. More help
  1. 1.0 1.1 1.2 Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci 124(1), 1-22, 10.1093/toxsci/kfr218.
  2. 2.0 2.1 2.2 Denison, M. S., and Nagy, S. R. (2003). Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43, 309-34, 10.1146/annurev.pharmtox.43.100901.135828 100901.135828 [pii].
  3. 3.0 3.1 Gasiewicz, T. A., Henry, E. C., and Collins, L. L. (2008). Expression and activity of aryl hydrocarbon receptors in development and cancer. Crit Rev Eukaryot Gene Expr 18(4), 279-321, 4de8c9fe5b6af78b,714c550a3fb330d1 [pii].
  4. Nguyen, L. P., and Bradfield, C. A. (2008). The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 21(1), 102-16, 10.1021/tx7001965.
  5. Bohonowych J.E. and Denison M.S., (2007) Persistent binding of ligands to the aryl hydrocarbon receptor Toxicol Sci 98, 99-109.
  6. Milbrath M.O., Wenger Y., Chang C.W., Emond C., Garabrant D., Gillespie B.W., and Jolliet O., (2009) Apparent half-lives of dioxins, furans, and polychlorinated biphenyls as a function of age, body fat, smoking status, and breast-feeding Environ Health Perspect 117, 417-25.
  7. Saurat J.H., Kaya G., Saxer-Sekulic N., Pardo B., Becker M., Fontao L., Mottu F., Carraux P., Pham X.C., Barde C., Fontao F., Zennegg M., Schmid P., Schaad O., Descombes P., and Sorg O., (2012) The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko Toxicol Sci 125, 310-7.
  8. Stinchcombe S., Buchmann A., Bock K.W., and Schwarz M., (1995) Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver Carcinogenesis 16, 1271-1275.
  9. National Toxicology Program (NTP). (2006a) NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage Studies) Natl Toxicol Program.Tech.Rep.Ser. 4-232.
  10. 10.0 10.1 Wincent E., Amini N., Luecke S., Glatt H., Bergman J., Crescenzi C., Rannug A., and Rannug U., (2009) The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans J Biol Chem 284, 2690-6.
  11. 11.0 11.1 Wincent E., Bengtsson J., Mohammadi Bardbori A., Alsberg T., Luecke S., Rannug U., and Rannug A., (2012) Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A 109, 4479-84.
  12. Aylward L.L. and Hays S.M., (2002) Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels J.Expo.Anal.Environ.Epidemiol. 12, 319-328.
  13. Hays S.M. and Aylward L.L., (2003) Dioxin risks in perspective: past, present, and future Regul.Toxicol.Pharmacol. 37, 202-217.
  14. Lorber M. (2002) A pharmacokinetic model for estimating exposure of Americans to dioxin-like compounds in the past, present, and future Sci.Total Environ. 288, 81-95.
  15. Lorber M., Patterson D., Huwe J., and Kahn H., (2009) Evaluation of background exposures of Americans to dioxin-like compounds in the 1990s and the 2000s Chemosphere 77, 640-51.
  16. Van den Berg M., Birnbaum L.S., Denison M., De V.M., Farland W., Feeley M., Fiedler H., Hakansson H., Hanberg A., Haws L., Rose M., Safe S., Schrenk D., Tohyama C., Tritscher A., Tuomisto J., Tysklind M., Walker N., and Peterson R.E., (2006) The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds Toxicol.Sci. 93, 223-241.
  17. Fromme H., Albrecht M., Boehmer S., Buchner K., Mayer R., Liebl B., Wittsiepe J., and Bolte G., (2009) Intake and body burden of dioxin-like compounds in Germany: the INES study Chemosphere 76, 1457-63.
  18. Windal I., Vandevijvere S., Maleki M., Goscinny S., Vinkx C., Focant J.F., Eppe G., Hanot V., and Van Loco J., (2010) Dietary intake of PCDD/Fs and dioxin-like PCBs of the Belgian population Chemosphere 79, 334-40.
  19. Nakatani T., Yamamoto A., and Ogaki S., (2010) A Survey of Dietary Intake of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Dioxin-like Coplanar Polychlorinated Biphenyls from Food During 2000-2002 in Osaka City, Japan Arch Environ Contam Toxicol, 10.1007/s00244-010-9553-y.
  20. Ahn K.C., Zhao B., Chen J., Cherednichenko G., Sanmarti E., Denison M.S., Lasley B., Pessah I.N., Kultz D., Chang D.P., Gee S.J., and Hammock B.D., (2008) In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens Environ Health Perspect 116, 1203-10.
  21. Bohonowych J.E., Zhao B., Timme-Laragy A., Jung D., Di Giulio R.T., and Denison M.S., (2008) Newspapers and newspaper ink contain agonists for the ah receptor Toxicol Sci 102, 278-90.
  22. El Gendy M.A.M., Soshilov A.A., Denison M.S., and El-Kadi A.O.S., (2012) Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. Food Chem Toxicol 50, 353-62.
  23. Heath-Pagliuso S., Rogers W.J., Tullis K., Seidel S.D., Cenijn P.H., Brouwer A., and Denison M.S., (1998) Activation of the Ah receptor by tryptophan and tryptophan metabolites Biochemistry 37, 11508-15.
  24. Hu W., Sorrentino C., Denison M.S., Kolaja K., and Fielden M.R., (2007) Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro Mol Pharmacol 71, 1475-86.
  25. Jeuken A., Keser B.J., Khan E., Brouwer A., Koeman J., and Denison M.S., (2003) Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits J Agric Food Chem 51, 5478-87.
  26. Knockaert M., Blondel M., Bach S., Leost M., Elbi C., Hager G.L., Nagy S.R., Han D., Denison M., Ffrench M., Ryan X.P., Magiatis P., Polychronopoulos P., Greengard P., Skaltsounis L., and Meijer L., (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins Oncogene 23, 4400-12.
  27. Lawrence B.P., Denison M.S., Novak H., Vorderstrasse B.A., Harrer N., Neruda W., Reichel C., and Woisetschlager M., (2008) Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound Blood 112, 1158-65.
  28. Phelan D., Winter G.M., Rogers W.J., Lam J.C., and Denison M.S., (1998) Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin Arch Biochem Biophys 357, 155-63.
  29. Seidel S.D., Winters G.M., Rogers W.J., Ziccardi M.H., Li V., Keser B., and Denison M.S., (2001) Activation of the Ah receptor signaling pathway by prostaglandins J Biochem Mol Toxicol 15, 187-96.
  30. Tiong C.T., Chen C., Zhang S.J., Li J., Soshilov A., Denison M.S., Lee L.S.-U., Tam V.H., Wong S.P., Xu H.E., and Yong E.-L., (2012) A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERα protein. Carcinogenesis 33, 1089-97.
  31. Williams S.N., Shih H., Guenette D.K., Brackney W., Denison M.S., Pickwell G.V., and Quattrochi L.C., (2000) Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression Chem Biol Interact 128, 211-29.
  32. Zhao B., Baston D.S., Hammock B., and Denison M.S., (2006) Interaction of diuron and related substituted phenylureas with the Ah receptor pathway J Biochem Mol Toxicol 20, 103-13.
  33. Zhao B., Degroot D.E., Hayashi A., He G., and Denison M.S., (2010) CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci 117, 393-403.
  34. Zhao B., Bohonowych J.E.S., Timme-Laragy A., Jung D., Affatato A.A., Rice R.H., Di Giulio R.T., and Denison M.S., (2013) Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One 8, e56860.
  35. Connor K.T., Harris M.A., Edwards M.R., Budinsky R.A., Clark G.C., Chu A.C., Finley B.L., and Rowlands J.C., (2008) AH receptor agonist activity in human blood measured with a cell-based bioassay: evidence for naturally occurring AH receptor ligands in vivo J Expo Sci Environ Epidemiol 18, 369-80.