API

Stressor: 205

Title

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pirinixic acid

Stressor Overview

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AOPs Including This Stressor

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AOP Name Evidence
PPARalpha-dependent liver cancer High

Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
pirinixic acid DTXSID4020290 Pirinixic acid 50892-23-4 SZRPDCCEHVWOJX-UHFFFAOYSA-N SZRPDCCEHVWOJX-UHFFFAOYSA-N

AOP Evidence

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PPARalpha-dependent liver cancer

There is no evidence text for this AOP




Event Evidence

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Increase, Mitogenic cell proliferation (hepatocytes)

WY-14,643 (pirinixic acid)

  1. WY-14,643 (pirinixic acid) is a potent PPARα activator, and its ability to stimulate cell proliferation has been reviewed in Corton et al. (2018).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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