AOPs Including This Stressor
|Lysosomal damage leading to liver inflammation|
|Aryl hydrocarbon receptor activation leading to uroporphyria||Strong|
Events Including This Stressor
There is no evidence text for this AOP
There is a strong association with iron overload and porphyrin accumulation (Gorman et al. 2002; Caballes et al. 2012). Mice that are resistant to chemical-induced porphyra, become susseptible when they are pre-treated with iron (Davies 2008).
Gorman, N., Ross, K. L., Walton, H. S., Bement, W. J., Szakacs, J. G., Gerhard, G. S., Dalton, T. P., Nebert, D. W., Eisenstein, R. S., Sinclair, J. F., and Sinclair, P. R. (2002) Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron. Hepatology 35 (4), 912-921.
Caballes, F.R., Sendi, H., Bonkovsky, H.L. (2012) Hepatitis C, porphyria cutanea tarda and liver iron: an update. Liver International. 32 (6), 880-93.
Davies, R., Clothier, B., Robinson, S. W., Edwards, R. E., Greaves, P., Luo, J., Gant, T. W., Chernova, T., and Smith, A. G. (2008) Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem. Res. Toxicol. 21 (2), 330-340.
This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.