API

Stressor: 232

Title

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Iron compounds

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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AOP Evidence

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Lysosomal damage leading to liver inflammation

There is no evidence text for this AOP



Aryl hydrocarbon receptor activation leading to uroporphyria

There is a strong association with iron overload and porphyrin accumulation (Gorman et al. 2002; Caballes et al. 2012).  Mice that are resistant to chemical-induced porphyra, become susseptible when they are pre-treated with iron (Davies 2008).

Gorman, N., Ross, K. L., Walton, H. S., Bement, W. J., Szakacs, J. G., Gerhard, G. S., Dalton, T. P., Nebert, D. W., Eisenstein, R. S., Sinclair, J. F., and Sinclair, P. R. (2002) Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron. Hepatology 35 (4), 912-921.

Caballes, F.R., Sendi, H., Bonkovsky, H.L. (2012) Hepatitis C, porphyria cutanea tarda and liver iron: an update. Liver International. 32 (6), 880-93.

Davies, R., Clothier, B., Robinson, S. W., Edwards, R. E., Greaves, P., Luo, J., Gant, T. W., Chernova, T., and Smith, A. G. (2008) Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem. Res. Toxicol. 21 (2), 330-340.

 

 

 




Event Evidence

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This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.



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