Stressor: 319
Title
Acrolein
Stressor Overview
AOPs Including This Stressor
AOP Name | Evidence |
---|---|
Oxidative stress Leading to Decreased Lung Function | Moderate |
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction | Moderate |
Chemical Table
Preferred name | DTXID | Casrn | jchem_inchi_key | indigo_inchi_key | User term |
---|---|---|---|---|---|
Acrolein | DTXSID5020023 | 107-02-8 | HGINCPLSRVDWNT-UHFFFAOYSA-N | HGINCPLSRVDWNT-UHFFFAOYSA-N | Acrolein |
References
Alexander, N.S., Blount, A., Zhang, S., Skinner, D., Hicks, S.B., Chestnut, M., et al. (2012). Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein. Laryngoscope 122(6), 1193-1197.
Borchers, M.T., Wesselkamper, S., Wert, S.E., Shapiro, S.D., and Leikauf, G.D. (1999). Monocyte inflammation augments acrolein-induced Muc5ac expression in mouse lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 277(3), L489-L497.
Chen, P., Deng, Z., Wang, T., Chen, L., Li, J., Feng, Y., et al. (2013). The potential interaction of MARCKS-related peptide and diltiazem on acrolin-induced airway mucus hypersecretion in rats. Intl. Immunopharmacol. 17(3), 625-632.
Costa, D.L., Kutzman, R.S., Lehmann, J.R., and Drew, R.T. (1986). Altered Lung Function and Structure in the Rat after Subchronic Exposure to Acrolein. Am. Rev. Respir. Dis. 133(2), 286-291.
Liu, D.-S., Wang, T., Han, S.-X., Dong, J.-J., Liao, Z.-L., He, G.-M., et al. (2009). p38 MAPK and MMP-9 cooperatively regulate mucus overproduction in mice exposed to acrolein fog. Intl. Immunopharmacol. 9(10), 1228-1235.
Moghe, A., Ghare, S., Lamoreau, B., Mohammad, M., Barve, S., McClain, C., et al. (2015). Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol. Sci. 143(2), 242-255.
Raju, S.V., Jackson, P.L., Courville, C.A., McNicholas, C.M., Sloane, P.A., Sabbatini, G., et al. (2013). Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. Am. J. Respir. Crit. Care Med. 188(11), 1321-1330.
Romet, S., Dubreuil, A., Baeza, A., Moreau, A., Schoevaert, D., and Marano, F. (1990). Respiratory tract epithelium in primary culture: Effects of ciliotoxic compounds. Toxicol. in vitro 4(4-5), 399-402.
Wang, T., Liu, Y., Chen, L., Wang, X., Hu, X.-R., Feng, Y.-L., et al. (2009). Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats. Eur. Respir. J. 33(5), 1122-1132.