Stressor: 319

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Acrolein

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Oxidative stress Leading to Decreased Lung Function	Moderate
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction	Moderate

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
Acrolein	DTXSID5020023	107-02-8	HGINCPLSRVDWNT-UHFFFAOYSA-N	HGINCPLSRVDWNT-UHFFFAOYSA-N	Acrolein

References

List of the literature that was cited for this prototypical stressor. More help

Alexander, N.S., Blount, A., Zhang, S., Skinner, D., Hicks, S.B., Chestnut, M., et al. (2012). Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein. Laryngoscope 122(6), 1193-1197.

Borchers, M.T., Wesselkamper, S., Wert, S.E., Shapiro, S.D., and Leikauf, G.D. (1999). Monocyte inflammation augments acrolein-induced Muc5ac expression in mouse lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 277(3), L489-L497.

Chen, P., Deng, Z., Wang, T., Chen, L., Li, J., Feng, Y., et al. (2013). The potential interaction of MARCKS-related peptide and diltiazem on acrolin-induced airway mucus hypersecretion in rats. Intl. Immunopharmacol. 17(3), 625-632.

Costa, D.L., Kutzman, R.S., Lehmann, J.R., and Drew, R.T. (1986). Altered Lung Function and Structure in the Rat after Subchronic Exposure to Acrolein. Am. Rev. Respir. Dis. 133(2), 286-291.

Liu, D.-S., Wang, T., Han, S.-X., Dong, J.-J., Liao, Z.-L., He, G.-M., et al. (2009). p38 MAPK and MMP-9 cooperatively regulate mucus overproduction in mice exposed to acrolein fog. Intl. Immunopharmacol. 9(10), 1228-1235.

Moghe, A., Ghare, S., Lamoreau, B., Mohammad, M., Barve, S., McClain, C., et al. (2015). Molecular mechanisms of acrolein toxicity: relevance to human disease. Toxicol. Sci. 143(2), 242-255.

Raju, S.V., Jackson, P.L., Courville, C.A., McNicholas, C.M., Sloane, P.A., Sabbatini, G., et al. (2013). Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function. Am. J. Respir. Crit. Care Med. 188(11), 1321-1330.

Romet, S., Dubreuil, A., Baeza, A., Moreau, A., Schoevaert, D., and Marano, F. (1990). Respiratory tract epithelium in primary culture: Effects of ciliotoxic compounds. Toxicol. in vitro 4(4-5), 399-402.

Wang, T., Liu, Y., Chen, L., Wang, X., Hu, X.-R., Feng, Y.-L., et al. (2009). Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats. Eur. Respir. J. 33(5), 1122-1132.