AOPs Including This Stressor
|Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity||High|
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
There is no evidence text for this AOP
Aminoglycoside antibiotics, like gentamicin, kill inner ear sensory hair cells in a variety of species including chickens, mice, and humans. The zebrafish (Danio rerio) has been used to study hair cell cytotoxicity in the lateral line organs of larval and adult animals. To assess the ototoxic effects of gentamicin, adult zebrafish received a single 250 mg/kg intraperitoneal injection of gentamicin and, 24 hours later, auditory evoked potential recordings (AEPs) revealed significant shifts in auditory thresholds compared to untreated controls (Uribe et al., 2013).
Uribe, P. M. et al. (2013) ‘Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)’, PLoS ONE, 8(3), p. 58755. doi: 10.1371/journal.pone.0058755.
Gentamicin causes significant inner ear sensory hair cell death and auditory dysfunction in zebrafish (Uribe et al., 2013).