API

Stressor: 344

Title

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Heptachlor

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Heptachlor DTXSID3020679 Heptachlor 76-44-8 FRCCEHPWNOQAEU-UHFFFAOYNA-N FRCCEHPWNOQAEU-UHFFFAOYSA-N

AOP Evidence

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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain

Organochlorine insecticides, including DDT, dieldrin, heptachlor, lindane, and β-hexachlorocyclohexane (β-HCH), have varied targets and mechanisms of action within the central nervous system that affect the function of sodium and calcium channels and transporters. They also interfer with γ-aminobutyric acid (GABA) neurotransmission by blocking specific GABA receptors, contributing to their neurotoxic effects (Narahashi et al., 1995). 




Event Evidence

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Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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