API

Stressor: 345

Title

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Endosulfan

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Endosulfan DTXSID1020560 Endosulfan 115-29-7 RDYMFSUJUZBWLH-UHFFFAOYNA-N RDYMFSUJUZBWLH-UHFFFAOYSA-N

AOP Evidence

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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain

See "Toxicological Profile for Endosulfan" (Agency for Toxic Substances and Disease Registry, 2000). Dose- and time-dependent correlations between picrotoxin site binding by chlorinated pesticides and convulsions were observed in mice (Cole and Casida 1986), whereas poisoning with the organochlorine insecticide endosulfan caused seizure, status epilepticus, or refractory status epilepticus in humans (Durukan et al. 2009; Moon et al. 2017; Moses and Peter 2010; Parbhu et al. 2009; Roberts et al. 2004), and eventually led to the death of a farmer (Roberts et al. 2004) and a toddler (Parbhu et al. 2009).




Event Evidence

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Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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