AOPs Including This Stressor
Events Including This Stressor
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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
See "Toxicological Profile for Endosulfan" (Agency for Toxic Substances and Disease Registry, 2000). Dose- and time-dependent correlations between picrotoxin site binding by chlorinated pesticides and convulsions were observed in mice (Cole and Casida 1986), whereas poisoning with the organochlorine insecticide endosulfan caused seizure, status epilepticus, or refractory status epilepticus in humans (Durukan et al. 2009; Moon et al. 2017; Moses and Peter 2010; Parbhu et al. 2009; Roberts et al. 2004), and eventually led to the death of a farmer (Roberts et al. 2004) and a toddler (Parbhu et al. 2009).