API

Stressor: 379

Title

?

Tris(1,3-dichloropropyl)phosphate - TDCPP

Stressor Overview

?


AOPs Including This Stressor

?


Events Including This Stressor

?


Chemical Table

?

User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Tris(1,3-dichloro-2-propyl)phosphate DTXSID9026261 TDCPP 13674-87-8 ASLWPAWFJZFCKF-UHFFFAOYSA-N ASLWPAWFJZFCKF-UHFFFAOYSA-N

AOP Evidence

?



Event Evidence

?


Reduction, Cumulative fecundity and spawning

Reduction of cumulative fecundity and spawning following exposure to low levels of TDCIPP (15, 46 and 90 nM) has been reported in 3 different zebrafish studies (Liu et al., 2013; Wang et al., 2015a; Zhu et al., 2015).




Stressor Info

?



Chemical/Category Description

?



Characterization of Exposure

?



References

?


  • Liu, X., Ji, K., Jo, A., Moon, H. B. and Choi, K. (2013). Effects of TDCPP or TPP on gene transcriptions and hormones of HPG axis, and their consequences on reproduction in adult zebrafish (Danio rerio). Aquat. Toxicol. 134–135, 104–111.
  • Wang, Q., Lam, J. C. W., Han, J., Wang, X., Guo, Y., Lam, P. K. S. and Zhou, B. (2015). Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish. Aquat. Toxicol. 160, 163–171.
  • Zhu, Y., Ma, X., Su, G., Yu, L., Letcher, R. J., Hou, J., Yu, H., Giesy, J. P. and Liu, C. (2015). Environmentally Relevant Concentrations of the Flame Retardant Tris(1,3-dichloro-2-propyl) Phosphate Inhibit Growth of Female Zebrafish and Decrease Fecundity. Environ. Sci. Technol. 49, 14579–14587.