AOPs Including This Stressor
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
|Epidermal growth factor||DTXSID5040469||Epidermal growth factor||62229-50-9|
Epidermal growth factor
1. Human epidermal growth factor (hEGF) treatment was shown to significantly increase replicative DNA synthesis, and Ki-67 mRNA levels in human hepatocytes of chimeric mice with humanized livers (human hepatocyte chimeric livers) (Yamada et al., 2014).
2. EGF has been shown to increase the proliferation of mouse (Bowen et al., 2014; Haines et al., 2018c), rat (Bowen et al., 2014; Haines et al., 2018c; Hodges et al., 2000), and human (Haines et al., 2018c; Parzefall et al., 1991) hepatocyte cultures as determined by increase in replicative DNA synthesis compared to appropriate controls.