API

Stressor: 407

Title

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Epidermal growth factor

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Epidermal growth factor DTXSID5040469 Epidermal growth factor 62229-50-9

AOP Evidence

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Event Evidence

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Increase, Mitogenic cell proliferation (hepatocytes)

Epidermal growth factor

1.         Human epidermal growth factor (hEGF) treatment was shown to significantly increase replicative DNA synthesis, and Ki-67 mRNA levels in human hepatocytes of chimeric mice with humanized livers (human hepatocyte chimeric livers) (Yamada et al., 2014).

2.         EGF has been shown to increase the proliferation of mouse (Bowen et al., 2014;  Haines et al., 2018c), rat (Bowen et al., 2014;  Haines et al., 2018c;  Hodges et al., 2000), and human (Haines et al., 2018c;  Parzefall et al., 1991) hepatocyte cultures as determined by increase in replicative DNA synthesis compared to appropriate controls.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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