API

Stressor: 439

Title

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Chemical:20384 Dexamethasone, minocycline, innamicaldehyde

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Decreased IL-1 production

Dexamethasone is one of the representatives that significantly suppress IL-1β production from monocytes (Finch-Arietta and Cochran 1991). Minocycline also suppress IL-1 signaling by the inhibition of caspase-1 activation, which is an essential enzyme for maturation of pro- IL-1β and the secretion of mature IL-1β(Vincent and Mohr 2007). Recently, it has been reported that cinnamicaldehyde suppresses serum IL-1β level in endotoxin poisoning mice (Xu, et al. 2016). These data suggest that chemicals as well as drugs can suppress IL-1 signaling through their inhibitory effects on IL-1β.




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