API

Stressor: 469

Title

?

Vinblastine sulfate

Stressor Overview

?


AOPs Including This Stressor

?


Events Including This Stressor

?


Chemical Table

?

User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Vinblastine sulfate DTXSID7047853 Vinblastine sulfate 18556-44-0 KDQAABAKXDWYSZ-PNYVAJAMSA-N KDQAABAKXDWYSZ-PNYVAJAMSA-N

AOP Evidence

?


Chemical binding to tubulin in oocytes leading to aneuploid offspring

Russo and Pacchierotti (1988) Dose-dependent significant increases of hyperhaploid oocytes at 0.23 mg/kg and 0.45 mg/kg. The percentages of hyperhaploid oocytes were 0.9 (2/219), 0.9 (1/111), 17.2 (26/151), and 59.7 (40/67), for controls, 0.09, 0.23, and 0.45 mg/kg, respectively. At higher doses almost all oocytes are arrested at the metaphase I stage.

Mailhes et al (1993) Significant increases of hyperhaploid oocytes at doses between 0.2 and 0.4 mg/kg. The percentages of hyperhaploid oocytes were 0.5 (1/218), 23.2 (149/641), 23.9 (81/339), 29.3 (72/246) and 30.7 (65/212), for controls, 0.2, 0.25, 0.3 and 0.4 mg/kg, respectively. At 0.6 mg/kg, almost all oocytes are arrested at the metaphase I stage.




Event Evidence

?


Disruption, Microtubule dynamics

There is no evidence text for this event.



Altered, Chromosome number

Vinblastine was tested in mice  at doses ranging from 0.9 to 9 mg/kg. Significant increses in hyperhaploid oocytes were seen at 0.23 and 0.45 mg/kg (Russo and Pacchierotti, 1988). Higher doses arrested all oocytes at the metaphase I stage, thus, preventing the manifestation of aneuploidy. These results were confirmed in another study (Maihles et al 1993). A study that followed the fate of arrested oocytes, showed that delaying collection of oocytes resulted in a reduction in metaphase I oocytes and a corresponding increase in diploid oocytes (Maihles and Marchetti, 1994).

A study in chinese hamster (Tateno et al 1995) showed that the increase in hyperhaploidy oocytes is similar to what is observed in the mouse with a dose that is 10 times lower.




Stressor Info

?



Chemical/Category Description

?



Characterization of Exposure

?



References

?