API

Stressor: 469

Title

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Vinblastine sulfate

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Vinblastine sulfate DTXSID7047853 Vinblastine sulfate 18556-44-0 KDQAABAKXDWYSZ-PNYVAJAMSA-N KDQAABAKXDWYSZ-PNYVAJAMSA-N

AOP Evidence

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Chemical binding to tubulin in oocytes leading to aneuploid offspring

Russo and Pacchierotti (1988) Dose-dependent significant increases of hyperhaploid oocytes at 0.23 mg/kg and 0.45 mg/kg. The percentages of hyperhaploid oocytes were 0.9 (2/219), 0.9 (1/111), 17.2 (26/151), and 59.7 (40/67), for controls, 0.09, 0.23, and 0.45 mg/kg, respectively. At higher doses almost all oocytes are arrested at the metaphase I stage.

Mailhes et al (1993) Significant increases of hyperhaploid oocytes at doses between 0.2 and 0.4 mg/kg. The percentages of hyperhaploid oocytes were 0.5 (1/218), 23.2 (149/641), 23.9 (81/339), 29.3 (72/246) and 30.7 (65/212), for controls, 0.2, 0.25, 0.3 and 0.4 mg/kg, respectively. At 0.6 mg/kg, almost all oocytes are arrested at the metaphase I stage.




Event Evidence

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Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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