AOPs Including This Stressor
Events Including This Stressor
BIO (6-bromoindirubin-3’-oxime) inhibits GSK3beta (Wu et al., 2015).
Embryos were treated with chemicals from 14 hpf to 18 hpf, immediately before the advent of gbx2 expression in the telencephalon, and then gbx2 expression was examined in this brain region . In embryos treated with BIO, a selective GSK3 inhibitor that activates Wnt signaling (Sato et al., 2004), gbx2 expression was specifically repressed in the telencephalon, but was unaffected or weakly activated in the isthmus and otic vesicle (OV).