AOPs Including This Stressor
|Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR||Moderate|
Events Including This Stressor
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
There is no evidence text for this AOP
EGFR phosphorylation increased in A549 lung cancer cells treated with 1 µM benzo[a]pyrene for 4 or 2 weeks (Kometani et al., 2009).
Treatment of immortalized human bronchial epithelial HBEC-2 and BEAS-2B cells with BPDE for 2 h increased EGFR activation in a dose-dependent manner (Xu et al., 2012).