API

Stressor: 51

Title

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Selected AHR Ligands

Stressor Overview

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AOPs Including This Stressor

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This table is automatically generated and lists AOP’s including this stressor and their Evidence.



Events Including This Stressor

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This table is automatically generated and lists KE’s including this stressor.



Chemical Table

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The Chemical Table lists chemicals associated with a stressor. This table contains information about the User’s term for a chemical, the DTXID, Preferred name, CAS number, JChem InChIKey, and Indigo InChIKey.

Instructions

To add a chemical associated with a particular stressor, next to the Chemical Table click ‘Add chemical.’ This will redirect you to a page entitled “New Stressor Chemical.’ The dialog box can be used to search for chemical by name, CAS number, JChem InChIKey, and Indigo InChIKey. Searching by these fields will bring forward a drop down list of existing stressor chemicals formatted as “CAS- preferred name” “JChem InChIKey – preferred name” or “Indigo InChIKey- preferred name” depending on which field you perform the search. Select an entity from the drop down list and click ‘Add chemical.’ This will return you to the Stressor Page, where the new record should be in the ‘Chemical Table’ on the page.


AOP Evidence

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This table is automatically generated and includes the AOPs with this associated stressor as well as the evidence text from this AOP Stressor.



Event Evidence

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This table is automatically generated and includes the Events with this associated stressor as well as the evidence text from this Event Stressor.



Stressor Info

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Chemical/Category Description

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Chemical properties for a selection of representative AHR ligands are provided in Table 3 in lieu of listing them separately.
Table 2 alt text
Table 3: Chemical and AHR binding properties of selected AHR ligands

This table also provides the EC50, which itself is a measure of potency and one of the determinants of sustained AHR activation. These representative ligands demonstrate the diversity in chemical properties modelling pharmacokinetics and bioavailability as well as sources, including anthropogenic chemicals, dietary constituents, and endogenous substances formed in vivo.



Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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List the bibliographic references to original papers, books or other documents used to support the Stressor.

Instructions

To edit the “References” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “References” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “References” section on the page.