AOPs Including This Stressor
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
After in vitro exposure, bipolar spindle formation and chromosome alignment at the metaphase plate are severely disturbed in oocytes. Six hr later, the percentage of aneuploid oocytes is significantly increased about the control level (Eichenlaub-RItter et al 2007).
Dose related increases in hyperhaploid oocytes after in vitro treatement. The lowest effective tested concentration was 3.75 microM (Eichenlaub-Ritter et al 2007). This study provides evidence that spindle and chromosome congression defects precede the observation of aneuploid oocytes.