API

Stressor: 512

Title

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2-Methoxyestradiol

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
2-Methoxyestradiol DTXSID3040938 2-Methoxyestradiol 362-07-2 CQOQDQWUFQDJMK-SSTWWWIQSA-N CQOQDQWUFQDJMK-SSTWWWIQSA-N

AOP Evidence

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Event Evidence

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Altered, Meiotic chromosome dynamics

After in vitro exposure, bipolar spindle formation and chromosome alignment at the metaphase plate are severely disturbed in oocytes. Six hr later, the percentage of aneuploid oocytes is significantly increased about the control level (Eichenlaub-RItter et al 2007).



Altered, Chromosome number

Dose related increases in hyperhaploid oocytes after in vitro treatement. The lowest effective tested concentration was 3.75 microM (Eichenlaub-Ritter et al 2007). This study provides evidence that spindle and chromosome congression defects precede the observation of aneuploid oocytes.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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