API

Stressor: 521

Title

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Bisphenol A

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Bisphenol A DTXSID7020182 Bisphenol A 80-05-7 IISBACLAFKSPIT-UHFFFAOYSA-N IISBACLAFKSPIT-UHFFFAOYSA-N

AOP Evidence

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Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)

There is no evidence text for this AOP




Event Evidence

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Binding to estrogen receptor (ER)-α in immune cells

There is no evidence text for this event.



Induction of GATA3 expression

GATA3 expression is induced in Th cells primed by dendritic cells exposed to BPA (Guo H. 2010).  Purified naive T cells were cultured and expanded under Th1 culture conditions in the presence or absence of 0.3 μM 4-HT (Research Biochemicals Institute) for 2 weeks starting from days 1, 7, 14, or 21 (Kurata H. 1999).



Increase of Th2 cells producing IL-4

Mouse lymphocytes stimulated with a massive amount of BPA (50 μM) were Th2 polarized, with prominent elevation of IL-4 as well as IL-10 (Lee J. 2010).  Similarly, BPA enhanced IL-4 production in antigen-activated T cells by ELISA or RT-PCR, although the concentrations of BPA that they utilized (10-50 μM) were high (Lee MH. 2003).  In this experiment, IL-4 level is confirmed baseline when treated with anti-CD4 mAb.  Exposure to BPA in adulthood mice promoted antigen-stimulated levels of IL-4, IL-10, and IL-13, but not IFN-γ (Huimin Y. 2008).



Increase of anti-DNA antibody from autoreactive B cell

BPA as well as E2 and diethylstilbestrol (DES) enhanced anti-Br-RBC autoantibody production by B1 cells in vivo.  IgM production by B1 cells in the presence of ED was more prominent on aged BWF1 mice developing lupus nephritis. (Yurino H. 2004). 

In a murine model of SLE, BPA increased the number of B cells producing autoantibodies, and IgM antibody secretion by B1 cells was augmented (Yurino H. 2004).  

To examine a direct effect of endocrine disruptors on IgM antibody production by B1 or B2 cells, B1 cells were prepared from peritoneal cells and B2 cells from spleen, B1 or B2 cells were cultured in the presence of endocrine disruptors (E2: 100 nM, DES: 100 nM, BPA: 1 μM) for 4 days (Yurino H. 2004). 



Exacerbation of systemic lupus erythematosus (SLE)

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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