API

Stressor: 549

Title

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Atorvastatin

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Atorvastatin DTXSID8029868 Atorvastatin 134523-00-5 XUKUURHRXDUEBC-KAYWLYCHSA-N XUKUURHRXDUEBC-KAYWLYCHSA-N

AOP Evidence

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Event Evidence

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Decreased, cholesterol

Male and female zebrafish fed atorvastatin alone or in combination with gemfibrozil have decreased whole-body cholesterol (Al-Habsi et al., 2016)

Atorvastatin is a statin drug that lowers cholesterol by inhibiting HMG-CoA reductase. Other chemical that work by the same mechanism can be found at: https://comptox.epa.gov/dashboard/chemical_lists/STATINS




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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