API

Stressor: 557

Title

?

Triticonazole

Stressor Overview

?


AOPs Including This Stressor

?


Events Including This Stressor

?


Chemical Table

?

User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Triticonazole DTXSID0032655 Triticonazole 131983-72-7 PPDBOQMNKNNODG-UHFFFAOYNA-N PPDBOQMNKNNODG-UHFFFAOYSA-N

AOP Evidence

?



Event Evidence

?


Antagonism, Androgen receptor

Using hAR-EcoScreen Assay, triticonazole showed a LOEC for antagonisms of 0.2 uM and an IC50 of 0.3 (±0.01) uM (Draskau et al, 2019)

 



decrease, male anogenital distance

Triticonazole has been shown to cause decreased male AGD in rats following intrauterine exposure to 150 and 450 mg/kg bw/day (Draskau et al, 2019).



Decreased, Transcription of genes by AR

Using hAR-EcoScreen Assay, triticonazole showed a LOEC for antagonisms of 0.2 mM and an IC50 of 0.3 (±0.01) mM (Draskau et al. 2019).




Stressor Info

?



Chemical/Category Description

?



Characterization of Exposure

?



References

?


Draskau MK, Boberg J, Taxvig C, Pedersen M, Frandsen HL, Christiansen S, Svingen T (2019) In vitro and in vivo endocrine disrupting effects of the azole fungicides triticonazole and flusilazole. Environ Pollut 255: 113309