API

Stressor: 560

Title

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Cyproterone acetate

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Cyproterone acetate DTXSID5020366 Cyproterone acetate 427-51-0 UWFYSQMTEOIJJG-FDTZYFLXSA-N UWFYSQMTEOIJJG-FDTZYFLXSA-N

AOP Evidence

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Event Evidence

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Antagonism, Androgen receptor

Using the AR-CALUX reporter assay in antagonism mode, cyproterone acetate showed an IC50 of 7.1 nM (Sonneveld et al, 2005).



Decreased, Transcription of genes by AR

Using analysis of androgen-regulated gene expression in the LNCaP prostate cancer cell line (Ngan et al. 2009) and using the AR-CALUX reporter assay in antagonism mode, cyproterone acetate showed an IC50 of 7.1 nM (Sonneveld et al. 2005).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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