Stressor: 628
Title
cell free mitochondrial DNA (mtDNA)
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
AOP Evidence
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD)
Zhang et.al., 2014. Mitochondrial DNA induces inflammation and increases TLR9/NF-kappa B expression in lung tissue. DOI: 10.3892/ijmm.2014.1650
Williamson et. al., 2014. Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects. doi: 10.1097/SLA.0b013e3182a4ea46
Pinti et.al., 2014. Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for " inflamm- aging" DOI: 10.1002/eji.201343921
Krychtiuk et. al., 2015. Mitochondrial DNA and Toll-Like Receptor-9 Are Associated With Mortality in Critically Ill Patients. doi: 10.1097/CCM.0000000000001311
Harrington et.al., 2017. Mitochondrial DNA in Sepsis doi: 10.1097/MCC.0000000000000427
Huang et. al., 2020. Prognostic value of plasma mitochondrial DNA in acute respiratory distress syndrome (ARDS): a single-center observational study. doi: 10.21037/jtd.2020.02.49
Faust et. al., 2020. Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients. doi.org/10.1016/j.chest.2019.09.028
Event Evidence
Induced Toll Like Receptor (TLR) Dysregulation
There is no evidence text for this event.