API

Stressor: 63

Title

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Thioacetamide

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Alkylation, Protein

Chemical Table

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AOP Evidence

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Protein Alkylation leading to Liver Fibrosis

see the chemical list under overall assessment




Event Evidence

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Alkylation, Protein

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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Hajovsky et al, 2012, Metabolism and Toxicity of Thioacetamide and ThioacetamideS‑Oxide in Rat HepatocytesChem. Res. Toxicol. 2012, 25, 1955−19

Sarma et al. Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites. Chem Res Toxicol. 2012 Sep 17;25(9):1868-77.

Akhtar and Sheikh, An overview of thioacetamide-induced hepatotoxicity. Toxin Reviews. 2013; 32,(3): 43-46.

Staňková et al, The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro. 2010 Dec;24(8):2097-103.