AOPs Including This Stressor
|Protein Alkylation leading to Liver Fibrosis||Strong|
Events Including This Stressor
see the chemical list under overall assessment
There is no evidence text for this event.
Characterization of Exposure
Hajovsky et al, 2012, Metabolism and Toxicity of Thioacetamide and ThioacetamideS‑Oxide in Rat HepatocytesChem. Res. Toxicol. 2012, 25, 1955−19
Sarma et al. Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites. Chem Res Toxicol. 2012 Sep 17;25(9):1868-77.
Akhtar and Sheikh, An overview of thioacetamide-induced hepatotoxicity. Toxin Reviews. 2013; 32,(3): 43-46.
Staňková et al, The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro. 2010 Dec;24(8):2097-103.