API

Stressor: 63

Title

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Thioacetamide

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Alkylation, Protein

Chemical Table

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The Chemical Table lists chemicals associated with a stressor. This table contains information about the User’s term for a chemical, the DTXID, Preferred name, CAS number, JChem InChIKey, and Indigo InChIKey.

Instructions

To add a chemical associated with a particular stressor, next to the Chemical Table click ‘Add chemical.’ This will redirect you to a page entitled “New Stressor Chemical.’ The dialog box can be used to search for chemical by name, CAS number, JChem InChIKey, and Indigo InChIKey. Searching by these fields will bring forward a drop down list of existing stressor chemicals formatted as “CAS- preferred name” “JChem InChIKey – preferred name” or “Indigo InChIKey- preferred name” depending on which field you perform the search. Select an entity from the drop down list and click ‘Add chemical.’ This will return you to the Stressor Page, where the new record should be in the ‘Chemical Table’ on the page.


AOP Evidence

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Protein Alkylation leading to Liver Fibrosis

see the chemical list under overall assessment




Event Evidence

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Alkylation, Protein

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Instructions

To edit the “ Stressor Description” section, on a KER page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Stressor Description” section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Stressor Description”  section on the page.



Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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Hajovsky et al, 2012, Metabolism and Toxicity of Thioacetamide and ThioacetamideS‑Oxide in Rat HepatocytesChem. Res. Toxicol. 2012, 25, 1955−19

Sarma et al. Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites. Chem Res Toxicol. 2012 Sep 17;25(9):1868-77.

Akhtar and Sheikh, An overview of thioacetamide-induced hepatotoxicity. Toxin Reviews. 2013; 32,(3): 43-46.

Staňková et al, The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro. 2010 Dec;24(8):2097-103.