AOPs Including This Stressor
|Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)||Moderate|
Events Including This Stressor
|Inhibition of Fyna|
There is no evidence text for this AOP
Rosmarinic acid, a secondary metabolite of herbal plants, was discovered as a new Fyna kinase inhibitor using immunochemical and in silico methods. Kinetic data implicate that rosmarinic acid inhibits Fyna kinase in a linear-mixed type of inhibition. In this type of reversible inhibition, a compound can interact both with the free enzyme and with the enzyme-substrate complex at a site other than the active site (Jelić et al., 2007).
Characterization of Exposure
Jelić, D., Mildner, B., Koštrun, S., Nujić, K., Verbanac, D., Čulić, O., Antolović, R., & Brandt, W. (2007). Homology modeling of human Fyn kinase structure: Discovery of rosmarinic acid as a new Fyn kinase inhibitor and in Silico study of its possible binding modes. Journal of Medicinal Chemistry, 50(6), 1090–1100. https://doi.org/10.1021/jm0607202