Paraoxon is an active metabolite of OP pesticide parathion which has been weaponized and used as a chemical-warfare agent that yields high mortality (Laxmikant 2014). Paraoxon is one of the most potent cholinesterase-inhibiting insecticides which is easily absorbed through skin and has been used to study acute and chronic effects of organophosphate intoxication (Deshpande LS et al., 2014). There is strong literature evidence demonstrating inhibition of AChE by paraoxon exposure leading to neurotoxicity. Paroxon inhibition of the enzyme AChE also potentially leads to enhanced glutamate release, diminished GABA uptake, oxidative damage, and neurodegeneration (Farizatto KLG et al., 2017). AChE inhibition and subsequent increased ACh levels can trigger seizures and cause neuronal and excitotoxic damage in the brain. Asymptomatic low-level exposure to such anticholinesterase toxins can also leave the brain vulnerable or even cause it to exhibit neurological problems later in life. Paraoxon exposure initiates a pathogenic cascade involving seizure events and subsequent signs of damage including unique presynaptic vulnerability and associated behavioral deficits (Farizatto KLG et al., 2017). Paraoxon-mediated synaptotoxicity is also associated with enhanced production of oxidative stress as well as integrin adhesion responses (Farizatto KLG et al., 2017).