AOPs Including This Stressor
|Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function||Moderate|
Events Including This Stressor
Ethyl-parathion is among the most highly toxic chemicals registered with US Environmental Protection Agency (USEPA, -738-F00-009 Sept, 2000). Specifically, ethyl-parathion has high acute toxicity potential by causing AChE inhibition and is listed as having Toxicity Category 1 for acute eye, skin, and inhalation effects. Additionally, ethyl-parathion is a potent plasma, red blood cell and brain acetyl cholinesterase inhibitor. It is toxic by all routes of exposure and cholinesterase inhibition occurs following acute, subchronic and chronic exposures (USEPA -738-F00-009 Sept, 2000). Cholinergic toxicity and even death from parathion is reported subsequent suicidal ingestion, accidental exposure and occupational exposure (Hill et al., 1990; Jaga and Dharmani, 2006; Lores et al., 1978; Orsorio et al, 1991). In large doses, methyl-parathion, ethyl-parathion, and other organophosphorus insecticides share a common mechanism of toxicity via inhibition of the activity of AChE enzymes in the nervous system, resulting in excess ACh at nerve terminals, and producing acute symptoms such as nausea, vomiting, cholinergic effects, weakness, paralysis, and seizures (CDC, 2009).