Stressor: 655

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Ozone

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Oxidative stress Leading to Decreased Lung Function	Moderate
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction	Moderate

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
Ozone	DTXSID0021098	10028-15-6	CBENFWSGALASAD-UHFFFAOYSA-N	CBENFWSGALASAD-UHFFFAOYSA-N	Ozone

References

List of the literature that was cited for this prototypical stressor. More help

Allegra, L., Moavero, N., and Rampoldi, C. (1991). Ozone-induced impairment of mucociliary transport and its prevention with N-acetylcysteine. Am. J. Med. 91(3), S67-S71.

Gosepath, J., Schaefer, D., Brommer, C., Klimek, L., Amedee, R.G., and Mann, W.J. (2000). Subacute Effects of Ozone Exposure on Cultivated Human Respiratory Mucosa. Am.n J. Rhinol. 14(6), 411-418.

Kim, C.S., Alexis, N.E., Rappold, A.G., Kehrl, H., Hazucha, M.J., Lay, J.C., et al. (2011). Lung function and inflammatory responses in healthy young adults exposed to 0.06 ppm ozone for 6.6 hours. Am. J. Respir. Crit. Care Med. 183(9), 1215-1221.

Qu, F., Qin, X.-Q., Cui, Y.-R., Xiang, Y., Tan, Y.-R., Liu, H.-J., et al. (2009). Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells. Chemico-biol. Interact. 179(2-3), 219-226.

Tager, I.B., Balmes, J., Lurmann, F., Ngo, L., Alcorn, S., and Künzli, N. (2005). Chronic exposure to ambient ozone and lung function in young adults. Epidemiology, 751-759.