Stressor: 655
Title
Ozone
Stressor Overview
AOPs Including This Stressor
AOP Name | Evidence |
---|---|
Oxidative stress Leading to Decreased Lung Function | Moderate |
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction | Moderate |
Chemical Table
Preferred name | DTXID | Casrn | jchem_inchi_key | indigo_inchi_key | User term |
---|---|---|---|---|---|
Ozone | DTXSID0021098 | 10028-15-6 | CBENFWSGALASAD-UHFFFAOYSA-N | CBENFWSGALASAD-UHFFFAOYSA-N | Ozone |
References
Allegra, L., Moavero, N., and Rampoldi, C. (1991). Ozone-induced impairment of mucociliary transport and its prevention with N-acetylcysteine. Am. J. Med. 91(3), S67-S71.
Gosepath, J., Schaefer, D., Brommer, C., Klimek, L., Amedee, R.G., and Mann, W.J. (2000). Subacute Effects of Ozone Exposure on Cultivated Human Respiratory Mucosa. Am.n J. Rhinol. 14(6), 411-418.
Kim, C.S., Alexis, N.E., Rappold, A.G., Kehrl, H., Hazucha, M.J., Lay, J.C., et al. (2011). Lung function and inflammatory responses in healthy young adults exposed to 0.06 ppm ozone for 6.6 hours. Am. J. Respir. Crit. Care Med. 183(9), 1215-1221.
Qu, F., Qin, X.-Q., Cui, Y.-R., Xiang, Y., Tan, Y.-R., Liu, H.-J., et al. (2009). Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells. Chemico-biol. Interact. 179(2-3), 219-226.
Tager, I.B., Balmes, J., Lurmann, F., Ngo, L., Alcorn, S., and Künzli, N. (2005). Chronic exposure to ambient ozone and lung function in young adults. Epidemiology, 751-759.