AOPs Including This Stressor
Events Including This Stressor
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Normal human bronchial epithelial cells exposed to aerosolized nicotine showed decreased CFTR and BK conductance, CBF, ASL volume, and decreased expression of FOXJ1 and KCNMA1 (Garcia-Arcos et al., 2016).
Increased EGFR phosphorylation was seen in normal human bronchial epithelial cells following treatment with 500 μM nicotine for 1 h (Martínez-García et al., 2008) or with 1 nM nicotine for 48 h (Lupacchini et al., 2021). EGFR activation is also seen in human lung cancer cells (A549, H1975) following treatment with 100 nM nicotine (Wang et al., 2020), human dysplastic oral keratinocytes following treatment with up to 10 µM nicotine (Wisniewski et al., 2018).