API

Stressor: 66

Title

?

Perchlorate

Stressor Overview

?


AOPs Including This Stressor

?


Events Including This Stressor

?


Chemical Table

?

User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Perchlorate DTXSID6024252 Perchlorate 14797-73-0 VLTRZXGMWDSKGL-UHFFFAOYSA-M VLTRZXGMWDSKGL-UHFFFAOYSA-M

AOP Evidence

?


Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis

There is no evidence text for this AOP



Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment

There is no evidence text for this AOP




Event Evidence

?


Inhibition, Na+/I- symporter (NIS)

There is no evidence text for this event.



Decreased, Uptake of inorganic iodide

There is no evidence text for this event.



Decreased, Thyroxine (T4) in tissues

Inferred given effect of reduced thyroid hormone synthesis on lack of metamorphic changes in tissues.



Decreased, Triiodothyronine (T3) in tissues

Inferred given effect of reduced thyroid hormone synthesis on lack of metamorphic changes in tissues.



Altered, Amphibian metamorphosis

Perchlorate exposure during prometamorphosis in Xenopus laevis causes delayed/arrested metamorphosis.




Stressor Info

?



Chemical/Category Description

?



Characterization of Exposure

?



References

?