AOPs Including This Stressor
Events Including This Stressor
Ferreira et al. (2015) found that rat kidney mitochondria treated with varied sizes of gold nanoparticles (GNPs-10 and GNPs-30) had some complex inhibition as well as some complex activation. Acute exposure to GNPs-30 resulted in the inhibition of CIII, whereas GNPs-10 were able to significantly inhibit complex I activity (Ferreira et al., 2015). Chronic exposure to the GNPs-10 resulted in CII inhibition, while both GNPs-10 and 30 caused CII and CII-III activation when chronically exposed (Ferreira et al., 2015). The activation of CII and CII-III by GNPs-30 were likely a compensation mechanism for decreased activity from CIV (Ferreira et al., 2015).