Stressor: 723
Title
Zinc
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
---|---|---|---|---|---|
Zinc | DTXSID7035012 | Zinc | 7440-66-6 | HCHKCACWOHOZIP-UHFFFAOYSA-N | HCHKCACWOHOZIP-UHFFFAOYSA-N |
AOP Evidence
Event Evidence
Increase, Oxidative Stress
Yeh et al. (2011) investigated the effects of zinc treatment on rat kidneys and found that treatment with 150 μM or more for 2 weeks or more caused a time- and dose-dependant increase in lipid peroxidation. They also found that renal GSH content was decreased in the rats treated with 150 μM or more for 8 weeks (Yeh et al., 2011).
It should be noted that Hao et al. (2014) found that rat kidneys exposed to lower concentrations of zinc (such as 100 μM) for short time periods (such as 1 day), showed a protective effect against toxicity induced by other heavy metals, including uranium. Soussi, Gargouri, and El Feki (2018) also found that pre-treatment with a low concentration of zinc (10 mg/kg treatment for 15 days) protected the renal cells of rats were from changes in varying oxidative stress markers, such as lipid peroxidation, protein carbonyl, and GPx levels.
Occurrence, Kidney toxicity
Yeh et al. (2011) conducted a study on the effect of dietary zinc on rat renal functioning. In their study they found that both blood urea nitrogen and plasma creatinine levels were elevated in a dose-dependant manner when rats were treated with 100 to 600 ppm of zinc in their diet.
It should be noted however that at low concentrations zinc displays protective effects against the nephrotoxicity of other heavy metals (Soussi, Gargouri, and El Feki, 2018). When 10 mg/kg bodyweight of zinc was administered concurrently with 343.6 mg/kg bodyweight of lead, the zinc reduced the change in serum creatinine, LDH, and blood urea nitrogen levels from the control, in comparison to the lead only treatments. They also found that treating the rats with only zinc at this concentration caused non-significant changes in any of the nephrotoxicity markers (Soussi, Gargouri, and El Feki, 2018).
Oxidative Stress
Yeh et al. (2011) investigated the effects of zinc treatment on rat kidneys and found that treatment with 150 μM or more for 2 weeks or more caused a time- and dose-dependant increase in lipid peroxidation. They also found that renal GSH content was decreased in the rats treated with 150 μM or more for 8 weeks (Yeh et al., 2011).
It should be noted that Hao et al. (2014) found that rat kidneys exposed to lower concentrations of zinc (such as 100 μM) for short time periods (such as 1 day), showed a protective effect against toxicity induced by other heavy metals, including uranium. Soussi, Gargouri, and El Feki (2018) also found that pre-treatment with a low concentration of zinc (10 mg/kg treatment for 15 days) protected the renal cells of rats were from changes in varying oxidative stress markers, such as lipid peroxidation, protein carbonyl, and GPx levels.