AOPs Including This Stressor
Events Including This Stressor
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
WIN18466 (bis-diamine; ALDH1A2 inhibitor) administration to mice resulted in abnormal coronary vessel formation, a thin myocardium and low occurrence of epicardial epithelial to mesenchymal transition (EMT) (S. Wang et al., 2018).
WIN18446 (or bis-(dichloroacetyl)diamine) is an irreversible RALDH inhibitor (RALDH1, -2, and -3), that also can cause abnormal development of the aortic arch and outflow tract, coronary arteries, and the myocardium and also it can cause syndromes as tetralogy of Fallot in rats, mice and chick (Fujino et al., 2005; Kise et al., 2005; Kuribayashi & Roberts, 1993; Nishijima et al., 2000; Okamoto et al., 2004; Okishima et al., 1992; Tasaka et al., 1991; S. Wang et al., 2018).