API

Stressor: 9

Title

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Allyl Alcohol

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Alkylation, Protein

Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
allyl alcohol DTXSID8020044 Allyl alcohol 107-18-6 XXROGKLTLUQVRX-UHFFFAOYSA-N XXROGKLTLUQVRX-UHFFFAOYSA-N

AOP Evidence

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Protein Alkylation leading to Liver Fibrosis

Reference Compound or this AOP




Event Evidence

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Alkylation, Protein

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Instructions

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Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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Auerbach SS, Mahler J, Travlos GS, Irwin RD. A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein. Toxicology. 2008 Nov 20;253(1-3):79-88.

Huang L, Heinloth AN, Zeng ZB, Paules RS, Bushel PR. Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants. BMC Genomics. 2008 Jun 16;9:288.

Kehrer JP, Biswal SS. The molecular effects of acrolein. Toxicol Sci. 2000 Sep;57(1):6-15.

Jung SA, Chung YH, Park NH, Lee SS, Kim JA, Yang SH, et al. Experimental model of hepatic fibrosis following repeated periportal necrosis induced by allylalcohol. Scand J Gastroenterol. 2000 Sep;35(9):969-75.

Mohammad MK, Avila D, Zhang J, Barve S, Arteel G, McClain C, et al. Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):73-82.

Yamada T, Tanaka Y, Hasegawa R, Sakuratani Y, Yamada J, Kamata E, et al. A category approach to predicting the repeated-dose hepatotoxicity of allyl esters. Regul Toxicol Pharmacol. 2013 Mar;65(2):189-95.