Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 226 to 250 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
916 decreased succinate dehydrogenase activity (GO:0000104) 2118: Succinate dehydrogenase, inhibited
915 increased blood coagulation, fibrin clot formation (GO:0072378) Fibrin (CHEBI:5054) 1846: Thrombosis and Disseminated Intravascular Coagulation
914 decreased fibrinolysis (GO:0042730) 1846: Thrombosis and Disseminated Intravascular Coagulation
913 decreased fibrinolysis (GO:0042730) Fibrin (CHEBI:5054) None
912 occurrence abnormal blood coagulation (MP:0002551) blood (UBERON:0000178) 1845: Coagulation
911 decreased abnormal glutathione level (MP:0012603) glutathione (CHEBI:16856) 130: Depletion, GSH
910 increased glutathione binding (GO:0043295) glutathione conjugate (CHEBI:24335) 2131: Conjugation, GSH
909 occurrence viral entry into host cell (GO:0046718) viral protein (PR:000036197) 1738: SARS-CoV-2 cell entry
908 occurrence viral entry into host cell (GO:0046718) viral genome (GO:0019015) 1738: SARS-CoV-2 cell entry
907 decreased second-messenger-mediated signaling (GO:0019932) sonic hedgehog protein (PR:000014841) 2043: Decrease, Sonic Hedgehog second messenger production
906 decreased sonic hedgehog protein (PR:000014841) None
905 increased endocrine signaling (GO:0038002) estrone (CHEBI:17263) 2092: Promotion, Ovarian Cancer
904 increased goblet cell (CL:0000160) 2117: Increase, goblet cell number
903 decreased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) 1702: Suppression of T cell activation
902 increased eye opacity (MP:0009859) Lens (FMA:58241) 2083: Occurrence of Cataracts
901 functional change nitric oxide homeostasis (GO:0033484) endothelium (UBERON:0001986) 2067: Altered, Nitric Oxide Levels
900 occurrence blood vessel remodeling (GO:0001974) blood vessel (UBERON:0001981) 2069: Occurrence, Abnormal Vascular Remodeling
899 occurrence Blood vessel (FMA:63183) None
898 decreased decreased triiodothyronine level (MP:0005473) 3,3',5'-triiodothyronine (CHEBI:28774) 1003: Decreased, Triiodothyronine (T3)
897 decreased protein localization to cilium (GO:0061512) smoothened (PR:000015288) 2044: Decrease, Smoothend relocation and activation
896 decreased second-messenger-mediated signaling (GO:0019932) None
895 increased cleft upper lip (MP:0005170) 2042: Increase, Orofacial clefting
894 increased Cleft palate (HP:0000175) 2042: Increase, Orofacial clefting
893 decreased abnormal palatal shelf fusion at midline (MP:0009887) secondary palate (UBERON:0001716) None
892 decreased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) None