Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 326 to 350 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
816 increased carboxypeptidase activity (GO:0004180) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
815 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) 1854: Dysregulation, ACE2 expression and activity
814 decreased angiotensin-converting enzyme 2 (PR:000003622) None
813 increased regulation of peptidase activity (GO:0052547) angiotensin-converting enzyme (human) (PR:P12821) None
812 increased mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (human) (PR:Q9BYF1) None
811 increased glycosylation (GO:0070085) mucin-5AC (PR:000031343) 1910: Mucus Viscosity, Increased
810 functional change vision trait (VT:0002090) eye (UBERON:0000970) 1643: Altered, Visual function
809 decreased cftr isoform 1 (PR:000001045) None
808 decreased forkhead box protein J1 (PR:000007628) 1911: FOXJ1 Protein, Decreased
807 decreased motile cilium (GO:0031514) 1912: Motile Cilia Number/Length, Decreased
806 increased NLRP3 inflammasome complex assembly (GO:0044546) NLRP3 inflammasome complex (GO:0072559) 1895: NLRP3 inflammasome activity, increased
805 increased mucus secretion (GO:0070254) lung goblet cell (CL:1000143) 1251: Chronic, Mucus hypersecretion
804 increased translation (GO:0006412) mucin-5AC (PR:000031343) 962: Increase, Mucin production
803 occurrence phosphorylation (GO:0016310) epidermal growth factor receptor (PR:000006933) None
802 occurrence Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) 1908: Cilia Beat Frequency, Decreased
801 decreased Abnormal ciliary motility (HP:0012262) motile cilium (GO:0031514) None
800 decreased epithelial lining fluid (UBERON:0035963) 1907: Airway Surface Liquid Height, Decreased
799 increased proton binding (GO:1901691) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
798 decreased regulation of mitochondrial membrane potential (GO:0051881) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
797 increased oxidative phosphorylation uncoupler activity (GO:0017077) mitochondrion (GO:0005739) 1446: Decrease, Coupling of oxidative phosphorylation
796 decreased ATP synthesis coupled proton transport (GO:0015986) mitochondrion (GO:0005739) None
795 decreased mitochondrion (GO:0005739) None
794 decreased mucociliary clearance trait (VT:0001947) 1909: Mucociliary Clearance, Decreased
793 decreased regulation of cilium movement (GO:0003352) None
792 decreased epithelial cilium movement (GO:0003351) None