Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 351 to 375 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
791 decreased chloride channel activity (GO:0005254) 1906: Cystic Fibrosis Transmembrane Regulator Function, Decreased
790 decreased translation (GO:0006412) None
789 decreased transcription, DNA-templated (GO:0006351) None
788 decreased cellular response to type I interferon (GO:0071357) type I interferon receptor complex (GO:0038197) None
787 decreased type I interferon signaling pathway (GO:0060337) signalling molecule (CHEBI:62488) None
786 decreased pattern recognition receptor signaling pathway (GO:0002221) RNA viral genome (GO:0019022) None
785 morphological change retina layer formation (GO:0010842) retina (UBERON:0000966) 1877: Altered, retinal layer structure
784 increased vascular inflammation (MP:0001863) 1867: Bradykinin system, hyperactivated
783 increased vasodilation (GO:0042311) 1867: Bradykinin system, hyperactivated
782 increased increased vascular permeability (MP:0003070) 1867: Bradykinin system, hyperactivated
781 decreased negative regulation of blood coagulation (GO:0030195) 1866: Fibrinolysis, decreased
780 increased negative regulation of fibrinolysis (GO:0051918) 1866: Fibrinolysis, decreased
779 decreased microphthalmia (MP:0001297) eye (UBERON:0000970) 1878: Decreased, Eye size
778 decreased protein tyrosine kinase activity (GO:0004713) tyrosine-protein kinase fyna (zebrafish) (PR:Q6EWH2) 1884: Inhibition of Fyna
777 decreased mRNA transcription (GO:0009299) aromatase (PR:000006100) 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
776 decreased protein secretion (GO:0009306) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
775 decreased protein secretion (GO:0009306) None
774 increased deoxyribonucleic acid (CHEBI:16991) 1879: Bulky DNA adducts, increase
773 occurrence regulation of cellular response to drug (GO:2001038) 1651: Treatment-resistant gastric cancer
772 occurrence epithelial to mesenchymal transition (GO:0001837) cellular_component (GO:0005575) None
771 occurrence regulation of beta-catenin-TCF complex assembly (GO:1904863) beta-catenin-TCF complex (GO:1990907) 1755: beta-catenin activation
770 disrupted mRNA transcription (GO:0009299) angiotensin-converting enzyme 2 (PR:000003622) None
769 increased neuropilin binding (GO:0038191) None
768 increased protease binding (GO:0002020) None
767 increased endocytosis involved in viral entry into host cell (GO:0075509) None