Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 551 to 575 of 1145 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
595 increased hypovolemia (MP:0010128) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
594 increased acidosis (MP:0003031) 1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
593 decreased catalytic activity (GO:0003824) Vitamin K Epoxide Reductases (MESH:D064417) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
592 decreased signaling (GO:0023052) androgen receptor (PR:000004191) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
591 abnormal vitamin K metabolic process (GO:0042373) vitamin K (CHEBI:28384) 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
590 decreased hemostasis (GO:0007599) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
589 decreased blood coagulation factors (MESH:D001779) 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
588 occurrence anemia (MP:0001577) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
587 abnormal cellular detoxification (GO:1990748) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
586 decreased transport (GO:0006810) nutrient (CHEBI:33284) 1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
585 decreased carboxylation reaction (MI:1139) coagulation factor X (mouse) (PR:O88947) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
584 decreased carboxylation reaction (MI:1139) coagulation factor IX (mouse) (PR:P16294) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
583 decreased carboxylation reaction (MI:1139) coagulation factor VII (mouse) (PR:P70375) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
582 decreased carboxylation reaction (MI:1139) prothrombin (PR:000007299) 1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
581 abnormal wound healing (GO:0042060) 1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
580 abnormal hemostasis (GO:0007599) 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
579 increased reactive oxygen species (CHEBI:26523) None
578 abnormal role (MESH:D012380) 1108: Abnormal, Role change within caste
577 increased Viral load (MESH:D019562) 1109: Increased, Deformed Wing Virus levels
576 occurrence ischemia (MESH:D007511) kidney (UBERON:0002113) 1105: Occurrence, renal ischemia
575 increased 3,3',5-triiodo-L-thyronine (CHEBI:18258) 1116: Decreased, Triiodothyronine (T3) in tissues
574 increased metamorphosis (GO:0007552) 1101: Altered, Amphibian metamorphosis
573 increased mesothelioma (MESH:D008654) None
572 increased cell proliferation (GO:0008283) mesothelium (UBERON:0001136) 1089: Increased, Cell Proliferation (mesothelium)
571 increased cell death (GO:0008219) pleura (UBERON:0000977) 1086: persistent, cytotoxicity (pleura or peritoneum)