Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 626 to 650 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
626 increased cytokine production (GO:0001816) beta-nerve growth factor (PR:000011194) 1234: Production of nerve growth factor , Epithelial irritation
627 increased cytokine production (GO:0001816) interleukin-8 (PR:000001395) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
628 increased regulation of chemokine (C-X-C motif) ligand 1 production (GO:2000338) growth-regulated alpha protein (PR:000006063) 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation
629 increased antigen processing and presentation (GO:0019882) hapten (CHEBI:59174) 1236: Generation of novel epitopes , Antigen presentation
630 increased immune response (GO:0006955) 1237: Sensitization, Immune system
631 increased reflex (GO:0060004) sneezing (MESH:D012912) 1434: Irritation of nasal mucosa inducing sneeze reflex
632 increased oxidation-reduction process (GO:0055114) plasma membrane (GO:0005886) 1238: Activation of oxidative stress pathway
633 increased oxidation-reduction process (GO:0055114) protein (PR:000000001) 1238: Activation of oxidative stress pathway
634 increased oxidation-reduction process (GO:0055114) deoxyribonucleic acid (CHEBI:16991) 1238: Activation of oxidative stress pathway
635 decreased signaling (GO:0023052) sodium channel protein type 1 subunit alpha (PR:000002095) 584: Inhibition, sodium channel
636 decreased transport (GO:0006810) sodium(1+) (CHEBI:29101) 1176: Decreased, sodium conductance 2
637 decreased transport (GO:0006810) gamma-aminobutyric acid (CHEBI:16865) 1179: Decreased, GABA release
638 increased signaling (GO:0023052) estrogen receptor (PR:000007204) None
639 increased estrogen receptor binding (GO:0030331) deoxyribonucleic acid (CHEBI:16991) 1187: Increased, ER binding to DNA (classical pathway)
640 increased estrogen receptor binding (GO:0030331) serotransferrin (PR:000016261) 1188: Increased, ER binding to T.F. to DNA (non-classical pathway)
641 increased endothelial cell proliferation (GO:0001935) 1189: Increased, Proliferation (Endothelial cells)
642 increased endothelial cell migration (GO:0043542) 1190: Increased, Migration (Endothelial Cells)
643 increased signaling (GO:0023052) 1191: Increased, Non-genomic signaling
644 pathological Breast Neoplasms (MESH:D001943) 1193: N/A, Breast Cancer
645 functional change deoxyribonucleic acid (CHEBI:16991) 1194: Increase, DNA damage
646 morphological change extracellular matrix (GO:0031012) 1195: modulation, Extracellular Matrix Composition
647 increased epithelial cell (CL:0000066) 1196: Increased, Invasion
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages
650 increased angiogenesis (GO:0001525) 1213: Increased, Angiogenesis