Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 876 to 900 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
266 increased apoptotic process (GO:0006915)
265 decreased hormone biosynthetic process (GO:0042446) testosterone (CHEBI:17347)
264 decreased reproductive process (GO:0022414) 675: Reduced, Reproductive Success
263 decreased prostaglandin (CHEBI:26333) 685: Reduced, Prostaglandins, ovary
262 decreased ovulation (GO:0030728) 488: Decrease, Ovulation
261 increased signaling (GO:0023052) RAC-beta serine/threonine-protein kinase (PR:000003912) 484: Activation, AKT2
260 occurrence inflammatory response (GO:0006954) 486: systemic inflammation leading to hepatic steatosis
259 increased gene expression (GO:0010467) apolipoprotein B-100 (PR:000004145) 880: Increased, ApoB100
258 increased signaling (GO:0023052) microsomal triglyceride transfer protein large subunit MTTP (PR:000003392) 879: Activation, MTTP
257 decreased catalytic activity (GO:0003824) 17-beta-hydroxysteroid dehydrogenase 14 (PR:000008778) 482: Decreased, DHB4/HSD17B4
256 increased signaling (GO:0023052) nuclear receptor subfamily 0 group B member 2 (PR:000011391) 480: Activation, SHP
255 increased signaling (GO:0023052) bile acid receptor (PR:000011396) 479: Activation, NR1H4
254 increased signaling (GO:0023052) nuclear factor erythroid 2-related factor 2 (PR:000011170) 478: Activation, NRF2
253 increased biosynthetic process (GO:0009058) triglyceride (CHEBI:17855)
252 decreased gene expression (GO:0010467) hydroxymethylglutaryl-CoA synthase, mitochondrial (PR:000008638) 474: Down Regulation, HMGCS2
251 decreased gene expression (GO:0010467) carnitine O-palmitoyltransferase 1, liver isoform (PR:000005835) 472: Down Regulation, CPT1A
250 decreased signaling (GO:0023052) hepatocyte nuclear factor 3-beta (PR:000007603) 471: Inhibition, FoxA2
249 decreased signaling (GO:0023052) hepatocyte nuclear factor 4-alpha (PR:000008654) 461: Suppression, HNF4alpha
248 increased acetyl-CoA carboxylase activity (GO:0003989) acetyl-CoA carboxylase 1 (PR:000003596) 470: Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
247 increased gene expression (GO:0010467) fatty acid synthase (PR:000007348) 463: Up Regulation, FAS
246 increased triglyceride biosynthetic process (GO:0019432) triglyceride (CHEBI:17855) 454: Increased, Triglyceride formation
245 increased signaling (GO:0023052) sterol regulatory element-binding protein 1 (PR:000015611) 457: Activation, SREBF1
244 decreased signaling (GO:0023052) nuclear receptor subfamily 1 group I member 3 (PR:000011398) 456: Suppression, Constitutive androstane receptor, NR1l3
243 increased gene expression (GO:0010467) cytochrome P450 1A1 (PR:000006101) 80: Up Regulation, CYP1A1
242 increased receptor-mediated endocytosis (GO:0006898) low-density lipoprotein (CHEBI:39026) 467: Increased, LDL uptake