Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 926 to 950 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
926 functional change smooth muscle cell (CL:0000192) 2096: Occurrence, (Micro)vascular dysfunction
927 disrupted intercellular transport (GO:0010496) 2096: Occurrence, (Micro)vascular dysfunction
928 occurrence receptor binding (GO:0005102)
929 occurrence receptor-mediated endocytosis (GO:0006898) clathrin-coated vesicle membrane (GO:0030665) None
930 occurrence protein localization to endosome (GO:0036010) clathrin-coated vesicle membrane (GO:0030665) 2159: Influenza A virus (IAV) cell entry
931 occurrence receptor-mediated endocytosis (GO:0006898) influenzavirus hemagglutinin (PR:000049750) 2159: Influenza A virus (IAV) cell entry
932 occurrence membrane fusion (GO:0061025) vesicle membrane (GO:0012506) 2159: Influenza A virus (IAV) cell entry
933 occurrence inhibition of host DNA replication by virus (GO:0098673) interferon regulatory factor 3 complex (GO:0097072) None
934 occurrence toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
935 occurrence toll-like receptor 7 signaling pathway (GO:0034154) viral genome (GO:0019015) None
936 decreased toll-like receptor 3 signaling pathway (GO:0034138) viral genome (GO:0019015) None
937 decreased toll-like receptor 7 signaling pathway (GO:0034154) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
938 decreased toll-like receptor 3 signaling pathway (GO:0034138) influenzavirus NS gene translation product (PR:000044794) 2180: Immune mechanisms antagonized by viral proteins
939 decreased sexual reproduction (GO:0019953) 2147: Decreased, Viable Offspring
940 decreased decreased body weight (MP:0001262) 864: Decreased, Body Weight
941 increased acute-phase response (GO:0006953) None
942 increased Atherosclerosis (HP:0002621) 1443: Atherosclerosis
943 increased acute-phase response (GO:0006953) Acute phase proteins (N/A)
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
947 occurrence membrane fusion (GO:0061025) influenzavirus hemagglutinin (PR:000049750) None
948 occurrence protein import into nucleus (GO:0006606) viral RNA-directed RNA polymerase complex (GO:0031381) 2192: Influenza A Virus production increased
949 occurrence transcription, RNA-templated (GO:0001172) segmented viral genome (GO:0019017) 2192: Influenza A Virus production increased
950 occurrence nuclear export (GO:0051168) viral genome (GO:0019015) None