Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1026 increased cholesterol biosynthetic process (GO:0006695) 2270: Increased, cholesterol synthesis enzymes
1027 increased increased circulating LDL cholesterol level (MP:0000182) blood plasma (UBERON:0001969) None
1028 increased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347) 2272: Testosterone levels, increased
1029 increased hormone biosynthetic process (GO:0042446) 17beta-hydroxy-5alpha-androstan-3-one (CHEBI:16330) None
1030 increased regulation of androgen receptor signaling pathway (GO:0060765) androgen receptor (PR:000004191) 2274: Androgen receptor activation, increased
1031 increased Immunosuppression (IDO:0000610) 984: Impairment, T-cell dependent antibody response
1032 increased aromatase (PR:000006100) None
1033 increased androgen biosynthetic process (GO:0006702) 17beta-hydroxy-5alpha-androstan-3-one (CHEBI:16330) 2273: Dihydrotestosterone (DHT) levels, increased
1034 increased antigen presentation trait (VT:0001835) Human leukocyte antigen complex (FMA:84795) None
1035 increased alpha-beta T cell receptor complex (GO:0042105) None
1036 increased gene conversion (GO:0035822) alpha-beta T cell receptor complex (GO:0042105) None
1037 increased gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) None
1038 increased cell activation involved in immune response (GO:0002263) Peyer's patch B cell (CL:0002402) None
1039 increased cell activation involved in immune response (GO:0002263) B cell (CL:0000236) None
1040 increased Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) None
1041 increased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) None
1042 increased T cell migration (GO:0072678) T cell (CL:0000084) None
1043 increased dendritic cell migration (GO:0036336) professional antigen presenting cell (CL:0000145) None
1044 increased immune system process (GO:0002376) None
1045 decreased insulin-induced gene 1 protein (PR:000009056) None
1046 increased increased circulating total protein level (MP:0005568) sterol regulatory element-binding protein 2 (PR:000015612) 2269: Increased, Sterol Regulatory Element Binding Protein 2 (SREBP2) protein expression
1047 decreased decreased circulating total protein level (MP:0005567) insulin-induced gene 1 protein (PR:000009056) 2268: Decreased, insulin-induced gene 1 (INSIG1) protein activity
1048 increased increased circulating LDL cholesterol level (MP:0000182) low-density lipoprotein cholesterol (CHEBI:47774) 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
1049 increased increased circulating total protein level (MP:0005568) proprotein convertase subtilisin/kexin type 9 (PR:000012440) 2276: Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9)
1050 pathological Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) 2257: Celiac disease