API

Aop: 126

AOP Title

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Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation

Short name:

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α-noradrenergic- reduced fecundity

Authors

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Point of Contact

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Tammy Stoker

Contributors

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  • Tammy Stoker

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Decreased, Binding of NE to NE receptors on GnRH neurons September 16, 2017 10:16
Inhibition, Antgonism of NE receptor December 03, 2016 16:37
Decreased, GnRH cfos activity September 16, 2017 10:15
Decreased, GnRH pulsatility/release September 16, 2017 10:15
Decreased, LH Surge September 16, 2017 10:15
Delayed, Ovulation December 03, 2016 16:37
Decreased, Cortical granule release/distribution upon fertilization September 16, 2017 10:15
Altered, Formation of cortical envelope September 16, 2017 10:15
Abnormal, Sperm penetration (polyspermy) September 16, 2017 10:15
Altered, Chromosome number (polyploid) zygote September 16, 2017 10:15
Decreased, Decreased fecundity December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Antgonism of NE receptor Inhibition, Antgonism of NE receptor

Key Events

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Title Short name
Decreased, Binding of NE to NE receptors on GnRH neurons Decreased, Binding of NE to NE receptors on GnRH neurons
Decreased, GnRH cfos activity Decreased, GnRH cfos activity
Decreased, GnRH pulsatility/release Decreased, GnRH pulsatility/release
Decreased, LH Surge Decreased, LH Surge
Delayed, Ovulation Delayed, Ovulation
Decreased, Cortical granule release/distribution upon fertilization Decreased, Cortical granule release/distribution upon fertilization
Altered, Formation of cortical envelope Altered, Formation of cortical envelope
Abnormal, Sperm penetration (polyspermy) Abnormal, Sperm penetration (polyspermy)
Altered, Chromosome number (polyploid) zygote Altered, Chromosome number (polyploid) zygote

Adverse Outcome

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Title Short name
Decreased, Decreased fecundity Decreased, Decreased fecundity

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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