API XML

Aop: 126

AOP Title

?


Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation

Short name:

?

α-noradrenergic- reduced fecundity

Graphical Representation

?

Click to download graphical representation template

W1siziisijiwmtyvmtevmjkvnzc0tm9yywryzw5lcmdpyy5qcgcixsxbinailcj0ahvtyiisijuwmhg1mdaixv0?sha=b2b9fa8e86276706

Authors

?


Point of Contact

?


Tammy Stoker   (email point of contact)

Contributors

?


  • Tammy Stoker

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

?

Revision dates for related pages

Page Revision Date/Time
Decreased, Binding of NE to NE receptors on GnRH neurons September 16, 2017 10:16
Inhibition, Antgonism of NE receptor December 03, 2016 16:37
Decreased, GnRH cfos activity September 16, 2017 10:15
Decreased, GnRH pulsatility/release September 16, 2017 10:15
Decreased, LH Surge September 16, 2017 10:15
Delayed, Ovulation December 03, 2016 16:37
Decreased, Cortical granule release/distribution upon fertilization September 16, 2017 10:15
Altered, Formation of cortical envelope September 16, 2017 10:15
Abnormal, Sperm penetration (polyspermy) September 16, 2017 10:15
Altered, Chromosome number (polyploid) zygote September 16, 2017 10:15
Decreased, Decreased fecundity December 03, 2016 16:37

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
1 MIE 849 Inhibition, Antgonism of NE receptor Inhibition, Antgonism of NE receptor
2 KE 848 Decreased, Binding of NE to NE receptors on GnRH neurons Decreased, Binding of NE to NE receptors on GnRH neurons
3 KE 529 Decreased, GnRH cfos activity Decreased, GnRH cfos activity
4 KE 530 Decreased, GnRH pulsatility/release Decreased, GnRH pulsatility/release
5 KE 531 Decreased, LH Surge Decreased, LH Surge
6 KE 532 Delayed, Ovulation Delayed, Ovulation
7 KE 533 Decreased, Cortical granule release/distribution upon fertilization Decreased, Cortical granule release/distribution upon fertilization
8 KE 534 Altered, Formation of cortical envelope Altered, Formation of cortical envelope
9 KE 535 Abnormal, Sperm penetration (polyspermy) Abnormal, Sperm penetration (polyspermy)
10 KE 536 Altered, Chromosome number (polyploid) zygote Altered, Chromosome number (polyploid) zygote
11 AO 527 Decreased, Decreased fecundity Decreased, Decreased fecundity

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?