API

Aop: 162

AOP Title

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Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse

Short name:

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thyroid follicular cell adenomas and carcinomas

Authors

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Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)

Point of Contact

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Charles Wood

Contributors

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  • Charles Wood

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Increased, induction of UDPGT's in liver September 16, 2017 10:17
Increased, T4/T3 catabolism September 16, 2017 10:17
Decreased, serum T4/T3 September 16, 2017 10:17
Increased, Thyroid-stimulating hormone (TSH) September 16, 2017 10:17
Increased, Hypertrophy and proliferation (follicular cell) September 16, 2017 10:17
Increased, Hyperplasia (follicular cells) September 16, 2017 10:17
Increased Apoptosis, Adenomas/carcinomas (follicular cell) September 16, 2017 10:17
Increased, induction of UDPGT's in liver leads to Increased, T4/T3 catabolism December 03, 2016 16:38
Increased, T4/T3 catabolism leads to Decreased, serum T4/T3 December 03, 2016 16:38
Decreased, serum T4/T3 leads to Increased, Thyroid-stimulating hormone (TSH) December 03, 2016 16:38
Increased, Thyroid-stimulating hormone (TSH) leads to Increased, Hypertrophy and proliferation (follicular cell) December 03, 2016 16:38
Increased, Hypertrophy and proliferation (follicular cell) leads to Increased, Hyperplasia (follicular cells) December 03, 2016 16:38
Increased, Hyperplasia (follicular cells) leads to Increased Apoptosis, Adenomas/carcinomas (follicular cell) December 03, 2016 16:38
Phenobarbital November 29, 2016 18:42
thiazopyr November 29, 2016 18:42
Pyrethrins and Pyrethroids November 29, 2016 18:42

Abstract

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This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.


Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Key Events

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Title Short name
Increased, induction of UDPGT's in liver Increased, induction of UDPGT's in liver
Increased, T4/T3 catabolism Increased, T4/T3 catabolism
Decreased, serum T4/T3 Decreased, serum T4/T3
Increased, Thyroid-stimulating hormone (TSH) Increased, Thyroid-stimulating hormone (TSH)
Increased, Hypertrophy and proliferation (follicular cell) Increased, Hypertrophy and proliferation (follicular cell)
Increased, Hyperplasia (follicular cells) Increased, Hyperplasia (follicular cells)

Adverse Outcome

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Title Short name
Increased Apoptosis, Adenomas/carcinomas (follicular cell) Increased Apoptosis, Adenomas/carcinomas (follicular cell)

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus sp. Rattus sp. Strong NCBI
mouse Mus musculus Moderate NCBI

Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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1. Dellarco, V. L., McGregor, D., Berry, S. C., Cohen, S. M., and Boobis, A. R. (2006). Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action. Critical reviews in toxicology 36(10), 793-801, 10.1080/10408440600975242.

2. Finch, J. M., Osimitz, T. G., Gabriel, K. L., Martin, T., Henderson, W. J., Capen, C. C., Butler, W. H., and Lake, B. G. (2006). A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. Toxicology and applied pharmacology 214(3), 253-62, 10.1016/j.taap.2006.01.009.

3. Hurley, P. M. (1998). Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environmental health perspectives 106(8), 437-45.