Aop: 162
AOP Title
Short name:
thyroid follicular cell adenomas and carcinomasGraphical Representation
Click to download graphical representation templateAuthors
Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)
Point of Contact
Charles Wood (email point of contact)
Contributors
- Charles Wood
Status
| Author status | OECD status | OECD project | SAAOP status |
|---|---|---|---|
| Under development: Not open for comment. Do not cite | 1.29 | Under Development |
This AOP was last modified on January 27, 2018 15:34
Revision dates for related pages
| Page | Revision Date/Time |
|---|---|
| Increased, induction of UDPGT's in liver | September 16, 2017 10:17 |
| Increased, T4/T3 catabolism | September 16, 2017 10:17 |
| Decreased, serum T4/T3 | September 16, 2017 10:17 |
| Increased, Thyroid-stimulating hormone (TSH) | September 16, 2017 10:17 |
| Increased, Hypertrophy and proliferation (follicular cell) | September 16, 2017 10:17 |
| Increased, Hyperplasia (follicular cells) | September 16, 2017 10:17 |
| Increased Apoptosis, Adenomas/carcinomas (follicular cell) | September 16, 2017 10:17 |
| Increased, induction of UDPGT's in liver leads to Increased, T4/T3 catabolism | December 03, 2016 16:38 |
| Increased, T4/T3 catabolism leads to Decreased, serum T4/T3 | December 03, 2016 16:38 |
| Decreased, serum T4/T3 leads to Increased, Thyroid-stimulating hormone (TSH) | December 03, 2016 16:38 |
| Increased, Thyroid-stimulating hormone (TSH) leads to Increased, Hypertrophy and proliferation (follicular cell) | December 03, 2016 16:38 |
| Increased, Hypertrophy and proliferation (follicular cell) leads to Increased, Hyperplasia (follicular cells) | December 03, 2016 16:38 |
| Increased, Hyperplasia (follicular cells) leads to Increased Apoptosis, Adenomas/carcinomas (follicular cell) | December 03, 2016 16:38 |
| Phenobarbital | November 29, 2016 18:42 |
| thiazopyr | November 29, 2016 18:42 |
| Pyrethrins and Pyrethroids | November 29, 2016 18:42 |
Abstract
This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.
Background (optional)
Summary of the AOP
Events: Molecular Initiating Events (MIE)
Key Events (KE) Adverse Outcomes (AO)| Sequence | Type | Event ID | Title | Short name |
|---|
| 1 | KE | 1020 | Increased, induction of UDPGT's in liver | Increased, induction of UDPGT's in liver |
| 2 | KE | 1021 | Increased, T4/T3 catabolism | Increased, T4/T3 catabolism |
| 3 | KE | 1022 | Decreased, serum T4/T3 | Decreased, serum T4/T3 |
| 4 | KE | 1023 | Increased, Thyroid-stimulating hormone (TSH) | Increased, Thyroid-stimulating hormone (TSH) |
| 5 | KE | 1024 | Increased, Hypertrophy and proliferation (follicular cell) | Increased, Hypertrophy and proliferation (follicular cell) |
| 6 | KE | 1025 | Increased, Hyperplasia (follicular cells) | Increased, Hyperplasia (follicular cells) |
| 7 | AO | 1026 | Increased Apoptosis, Adenomas/carcinomas (follicular cell) | Increased Apoptosis, Adenomas/carcinomas (follicular cell) |
Relationships Between Two Key Events
(Including MIEs and AOs)
| Title | Adjacency | Evidence | Quantitative Understanding |
|---|
Network View
Stressors
| Name | Evidence Term |
|---|---|
| Phenobarbital | |
| thiazopyr | |
| Pyrethrins and Pyrethroids |
Life Stage Applicability
Taxonomic Applicability
Sex Applicability
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Evidence Assessment
Quantitative Understanding
Considerations for Potential Applications of the AOP (optional)
References
1. Dellarco, V. L., McGregor, D., Berry, S. C., Cohen, S. M., and Boobis, A. R. (2006). Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action. Critical reviews in toxicology 36(10), 793-801, 10.1080/10408440600975242.
2. Finch, J. M., Osimitz, T. G., Gabriel, K. L., Martin, T., Henderson, W. J., Capen, C. C., Butler, W. H., and Lake, B. G. (2006). A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. Toxicology and applied pharmacology 214(3), 253-62, 10.1016/j.taap.2006.01.009.
3. Hurley, P. M. (1998). Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environmental health perspectives 106(8), 437-45.