API

Aop: 194

AOP Title

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Hepatic nuclear receptor activation leading to altered amphibian metamorphosis

Short name:

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Hepatic nuclear receptor activation alters metamorphosis

Authors

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Jonathan T. Haselman, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <haselman.jon@epa.gov>

Sigmund J. Degitz, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <degitz.sigmund@epa.gov>

Michael W. Hornung, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <hornung.michael@epa.gov>

Point of Contact

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Jonathan Haselman

Contributors

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  • Jonathan Haselman

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Activation, Hepatic nuclear receptor(s) September 16, 2017 10:17
Increased, Hepatic thyroid hormone uptake/transport September 16, 2017 10:17
Induction, Upregulation of glucuronyltransferase activity September 16, 2017 10:14
Increase, Biliary excretion TH glucuronide September 16, 2017 10:14
Thyroxine (T4) in serum, Decreased September 17, 2017 18:37
Decreased, Thyroxine (T4) in tissues November 29, 2016 19:42
Decreased, Triiodothyronine (T3) in tissues November 29, 2016 19:43
Altered, Amphibian metamorphosis December 03, 2016 16:37
Activation, Hepatic nuclear receptor(s) leads to Increased, Hepatic thyroid hormone uptake/transport December 03, 2016 16:38
Activation, Hepatic nuclear receptor(s) leads to Induction, Upregulation of glucuronyltransferase activity December 03, 2016 16:38
Increased, Hepatic thyroid hormone uptake/transport leads to Increase, Biliary excretion TH glucuronide December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Activation, Hepatic nuclear receptor(s) Activation, Hepatic nuclear receptor(s)

Key Events

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Title Short name
Increased, Hepatic thyroid hormone uptake/transport Increased, Hepatic thyroid hormone uptake/transport
Induction, Upregulation of glucuronyltransferase activity Induction, Upregulation of glucuronyltransferase activity
Increase, Biliary excretion TH glucuronide Increase, Biliary excretion TH glucuronide
Thyroxine (T4) in serum, Decreased T4 in serum, Decreased
Decreased, Thyroxine (T4) in tissues Decreased, Thyroxine (T4) in tissues
Decreased, Triiodothyronine (T3) in tissues Decreased, Triiodothyronine (T3) in tissues

Adverse Outcome

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Title Short name
Altered, Amphibian metamorphosis Altered, Amphibian metamorphosis

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Development Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
African clawed frog Xenopus laevis Weak NCBI

Sex Applicability

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Sex Evidence
Unspecific Moderate

Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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