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Aop: 194

AOP Title

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Hepatic nuclear receptor activation leading to altered amphibian metamorphosis

Short name:

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Hepatic nuclear receptor activation alters metamorphosis

Graphical Representation

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Click to download graphical representation template

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Authors

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Jonathan T. Haselman, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <haselman.jon@epa.gov>

Sigmund J. Degitz, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <degitz.sigmund@epa.gov>

Michael W. Hornung, National Health and Environmental Effects Research Laboratory, US EPA, Duluth, MN, USA <hornung.michael@epa.gov>

Point of Contact

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Jonathan Haselman   (email point of contact)

Contributors

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  • Jonathan Haselman

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Activation, Hepatic nuclear receptor(s) September 16, 2017 10:17
Increased, Hepatic thyroid hormone uptake/transport September 16, 2017 10:17
Induction, Upregulation of glucuronyltransferase activity September 16, 2017 10:14
Increase, Biliary excretion TH glucuronide September 16, 2017 10:14
Thyroxine (T4) in serum, Decreased June 02, 2018 09:41
Decreased, Thyroxine (T4) in tissues November 29, 2016 19:42
Decreased, Triiodothyronine (T3) in tissues November 29, 2016 19:43
Altered, Amphibian metamorphosis December 03, 2016 16:37
Activation, Hepatic nuclear receptor(s) leads to Increased, Hepatic thyroid hormone uptake/transport December 03, 2016 16:38
Activation, Hepatic nuclear receptor(s) leads to Induction, Upregulation of glucuronyltransferase activity December 03, 2016 16:38
Increased, Hepatic thyroid hormone uptake/transport leads to Increase, Biliary excretion TH glucuronide December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1157 Activation, Hepatic nuclear receptor(s) Activation, Hepatic nuclear receptor(s)
2 KE 1158 Increased, Hepatic thyroid hormone uptake/transport Increased, Hepatic thyroid hormone uptake/transport
3 KE 295 Induction, Upregulation of glucuronyltransferase activity Induction, Upregulation of glucuronyltransferase activity
4 KE 401 Increase, Biliary excretion TH glucuronide Increase, Biliary excretion TH glucuronide
5 KE 281 Thyroxine (T4) in serum, Decreased T4 in serum, Decreased
6 KE 1093 Decreased, Thyroxine (T4) in tissues Decreased, Thyroxine (T4) in tissues
7 KE 1116 Decreased, Triiodothyronine (T3) in tissues Decreased, Triiodothyronine (T3) in tissues
8 AO 1101 Altered, Amphibian metamorphosis Altered, Amphibian metamorphosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activation, Hepatic nuclear receptor(s) leads to Increased, Hepatic thyroid hormone uptake/transport adjacent Moderate Low
Activation, Hepatic nuclear receptor(s) leads to Induction, Upregulation of glucuronyltransferase activity adjacent Moderate Low
Increased, Hepatic thyroid hormone uptake/transport leads to Increase, Biliary excretion TH glucuronide non-adjacent Low Low

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Development Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
African clawed frog Xenopus laevis Low NCBI

Sex Applicability

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Sex Evidence
Unspecific Moderate

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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