API XML

Aop: 197

AOP Title

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Sodium channel (Nav1.1) inhibition leading to population decline

Short name:

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Nav1.1 inhibition to population decline

Graphical Representation

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Click to download graphical representation template

Authors

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Kellie Fay

Point of Contact

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Kellie Fay   (email point of contact)

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Inhibition, sodium channel September 16, 2017 10:15
Decreased, sodium conductance 2 December 03, 2016 16:37
Decreased, GABA release December 03, 2016 16:37
Inhibition, sodium channel leads to Decreased, sodium conductance 2 December 03, 2016 16:38
Decreased, sodium conductance 2 leads to Decreased, GABA release December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 584 Inhibition, sodium channel Inhibition, sodium channel
2 KE 1176 Decreased, sodium conductance 2 Decreased, sodium conductance 2
3 KE 1179 Decreased, GABA release Decreased, GABA release

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, sodium channel leads to Decreased, sodium conductance 2 adjacent
Decreased, sodium conductance 2 leads to Decreased, GABA release adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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