API

Aop: 208

AOP Title

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Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure

Short name:

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JAK/STAT and TGF-beta pathways activation leading to reproductive failure

Authors

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Jinhee Choi, Nivedita Chatterjee, Hunbeen Kim, Jae-Seong Jeong

Point of Contact

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Jinhee Choi

Contributors

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  • Jinhee Choi

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on February 15, 2017 04:31

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Revision dates for related pages

Page Revision Date/Time
Activation, JAK/STAT pathway September 16, 2017 10:17
Activation, TGF-beta pathway September 16, 2017 10:17
Reproductive failure February 15, 2017 03:18
Activation, JAK/STAT pathway leads to Activation, TGF-beta pathway February 15, 2017 03:51
Activation, TGF-beta pathway leads to Reproductive failure February 15, 2017 03:52
UV-activated Titanium dioxide nanoparticles February 15, 2017 03:49

Abstract

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Titanium dioxide nanoparticles (TiO2NPs) are widely used nanoparticles (NPs) , whose catalytic activity is mainly due to photoactivation. UV activation influences toxicity of TiO2NPs, so in this AOP, UV-activated TiO2 nanoparticles were used as stressors. This AOP is constituted the KEs as JAK/STAT and TGF-beta pathways activation and AO as reproductive failure.


Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Key Events

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Title Short name
Activation, JAK/STAT pathway Activation, JAK/STAT pathway
Activation, TGF-beta pathway Activation, TGF-beta pathway

Adverse Outcome

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Title Short name
Reproductive failure Reproductive failure

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
Activation, JAK/STAT pathway leads to Activation, TGF-beta pathway Directly leads to
Activation, TGF-beta pathway leads to Reproductive failure Directly leads to

Network View

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Life Stage Applicability

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Life stage Evidence
All life stages

Taxonomic Applicability

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Term Scientific Term Evidence Link
Caenorhabditis elegans Caenorhabditis elegans NCBI

Sex Applicability

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Sex Evidence
Unspecific

Graphical Representation

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Click to download graphical representation template

W1siziisijiwmtcvmdivmtuvmjy5bg9jadd3nv9kquttvefux2fuzf9ur0zfymv0yv9wyxrod2f5c19hy3rpdmf0aw9ux2xlywrpbmdfdg9fcmvwcm9kdwn0axzlx2zhawx1cmuucg5nil0swyjwiiwidgh1bwiilci1mdb4ntawil1d?sha=ff54c3a5077d361b

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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