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Aop: 304

AOP Title

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TBX1 inhibition leading to congenital cardiac conotruncal anomalies

Short name:

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TBX1 inhibition leading to congenital cardiac conotruncal anomalies

Graphical Representation

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Click to download graphical representation template

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Authors

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Jinsoo Lee, Korea Institute of Toxicology

Wook-Joon Yu, Korea Institute of Toxicology

Ji-Seong Jeong, Korea Institute of Toxicology

Jung-Hwa Oh, Korea Institute of Toxicology

Point of Contact

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Jinsoo Lee   (email point of contact)

Contributors

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  • Jinsoo Lee
  • Wook-Joon Yu
  • Ji-Seong Jeong
  • Jung-Hwa Oh

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on August 13, 2019 00:56

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Revision dates for related pages

Page Revision Date/Time
Inhibition, TBX1 August 13, 2019 00:34
Disruption, Neural crest cell migration August 13, 2019 00:50
Disruption, Progenitor cells of second heart field August 13, 2019 00:51
Impairment, Fourth pharyngeal arch development August 13, 2019 00:53
Abnormalities, Cardiac outflow tract formation August 13, 2019 00:54
Anomalies, Congenital cardiac conotruncal August 13, 2019 00:56

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1680 Inhibition, TBX1 Inhibition, TBX1
2 KE 1681 Disruption, Neural crest cell migration Disruption, Neural crest cell migration
3 KE 1682 Disruption, Progenitor cells of second heart field Disruption, Progenitor cells of second heart field
4 KE 1683 Impairment, Fourth pharyngeal arch development Impairment, Fourth pharyngeal arch development
5 KE 1684 Abnormalities, Cardiac outflow tract formation Abnormalities, Cardiac outflow tract formation
6 AO 1685 Anomalies, Congenital cardiac conotruncal Anomalies, Congenital cardiac conotruncal

Relationships Between Two Key Events
(Including MIEs and AOs)

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Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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