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Aop: 343

AOP Title

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Sulfonylurea receptor binding leading to mortality

Short name:

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Sulfonylurea receptor binding leading to mortality

Graphical Representation

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Click to download graphical representation template

Authors

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Simon Schmid1, You Song1, Knut Erik Tollefsen1,2

1Norwegian Institute for Water Research (NIVA)

2Norwegian University of Life Sciences (NMBU)

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on May 08, 2020 07:25

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Revision dates for related pages

Page Revision Date/Time
Increase, Sulfonylurea receptor binding May 24, 2018 16:09
Increase, Cell membrane depolarization May 24, 2018 16:20
Increase, Opening of voltage-dependent calcium channel May 24, 2018 16:19
Decrease, Cuticular chitin synthesis May 24, 2018 15:58
Increase, Premature molting May 24, 2018 15:58
Increase, Mortality December 03, 2016 16:33
Increase, SUR binding leads to Increase, Cell membrane depolarization May 24, 2018 16:22
Increase, Cell membrane depolarization leads to Increase, Opening of voltage-dependent calcium channel May 24, 2018 16:23
Increase, Opening of voltage-dependent calcium channel leads to Decrease, Cuticular chitin synthesis May 24, 2018 16:23
Decrease, Cuticular chitin synthesis leads to Increase, Premature molting May 24, 2018 15:59
Increase, Premature molting leads to Increase, Mortality May 24, 2018 16:00
Teflubenzuron May 24, 2018 16:15
Diflubenzuron May 24, 2018 16:15
Glibenclamide May 24, 2018 16:26

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1525 Increase, Sulfonylurea receptor binding Increase, SUR binding
KE 1527 Increase, Cell membrane depolarization Increase, Cell membrane depolarization
KE 1526 Increase, Opening of voltage-dependent calcium channel Increase, Opening of voltage-dependent calcium channel
KE 1523 Decrease, Cuticular chitin synthesis Decrease, Cuticular chitin synthesis
KE 1524 Increase, Premature molting Increase, Premature molting
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, SUR binding leads to Increase, Cell membrane depolarization adjacent
Increase, Cell membrane depolarization leads to Increase, Opening of voltage-dependent calcium channel adjacent
Increase, Opening of voltage-dependent calcium channel leads to Decrease, Cuticular chitin synthesis adjacent
Decrease, Cuticular chitin synthesis leads to Increase, Premature molting adjacent
Increase, Premature molting leads to Increase, Mortality adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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