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Aop: 64

AOP Title

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Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility

Short name:

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Adult Leydig Cell Dysfunction

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Susan Laws   (email point of contact)

Contributors

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  • Susan Laws

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Glucocorticoid Receptor Agonist, Activation September 16, 2017 10:15
Repressed expression of steroidogenic enzymes September 16, 2017 10:15
Increased apoptosis, decreased number of adult Leydig Cells September 16, 2017 10:15
Reduction, Testosterone synthesis in Leydig cells September 16, 2017 10:14
Reduction, testosterone level September 16, 2017 10:14
Decreased sperm quantity or quality in the adult, Decreased fertility December 03, 2016 16:37
impaired, Fertility December 02, 2016 09:21
GR Agonist, Activation leads to Increased apoptosis, decreased Leydig Cells August 11, 2017 13:06
GR Agonist, Activation leads to Repressed expression of steroidogenic enzymes August 11, 2017 13:06
Increased apoptosis, decreased Leydig Cells leads to Reduction, Testosterone synthesis in Leydig cells August 11, 2017 13:07
Repressed expression of steroidogenic enzymes leads to Reduction, Testosterone synthesis in Leydig cells August 11, 2017 13:07
Reduction, Testosterone synthesis in Leydig cells leads to Reduction, testosterone level December 02, 2016 10:18
Reduction, testosterone level leads to Decreased sperm quantity or quality in the adult, Decreased fertility August 11, 2017 13:09
Decreased sperm quantity or quality in the adult, Decreased fertility leads to impaired, Fertility August 11, 2017 13:09

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 494 Glucocorticoid Receptor Agonist, Activation GR Agonist, Activation
2 KE 495 Repressed expression of steroidogenic enzymes Repressed expression of steroidogenic enzymes
3 KE 496 Increased apoptosis, decreased number of adult Leydig Cells Increased apoptosis, decreased Leydig Cells
4 KE 413 Reduction, Testosterone synthesis in Leydig cells Reduction, Testosterone synthesis in Leydig cells
5 KE 446 Reduction, testosterone level Reduction, testosterone level
6 KE 520 Decreased sperm quantity or quality in the adult, Decreased fertility Decreased sperm quantity or quality in the adult, Decreased fertility
7 AO 406 impaired, Fertility impaired, Fertility

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
GR Agonist, Activation leads to Increased apoptosis, decreased Leydig Cells adjacent
GR Agonist, Activation leads to Repressed expression of steroidogenic enzymes adjacent
Increased apoptosis, decreased Leydig Cells leads to Reduction, Testosterone synthesis in Leydig cells adjacent
Repressed expression of steroidogenic enzymes leads to Reduction, Testosterone synthesis in Leydig cells adjacent
Reduction, Testosterone synthesis in Leydig cells leads to Reduction, testosterone level adjacent
Reduction, testosterone level leads to Decreased sperm quantity or quality in the adult, Decreased fertility adjacent
Decreased sperm quantity or quality in the adult, Decreased fertility leads to impaired, Fertility adjacent

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus NCBI

Sex Applicability

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Sex Evidence
Male

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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