API

Aop: 73

AOP Title

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Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity

Short name:

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DBH inhibition

Authors

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Tammy Stoker, U.S. EPA

Point of Contact

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Tammy Stoker

Contributors

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  • Tammy Stoker

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Inhibition of Dopamine-beta-hydroxylase September 16, 2017 10:15
Decreased, Decreased fecundity December 03, 2016 16:37
Decreased, Synthesis of NE September 16, 2017 10:15
Decreased, GnRH cfos activity September 16, 2017 10:15
Decreased, GnRH pulsatility/release September 16, 2017 10:15
Decreased, LH Surge September 16, 2017 10:15
Delayed, Ovulation December 03, 2016 16:37
Decreased, Cortical granule release/distribution upon fertilization September 16, 2017 10:15
Altered, Formation of cortical envelope September 16, 2017 10:15
Abnormal, Sperm penetration (polyspermy) September 16, 2017 10:15
Altered, Chromosome number (polyploid) zygote September 16, 2017 10:15

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Inhibition of Dopamine-beta-hydroxylase Inhibition, Inhibition of Dopamine-beta-hydroxylase

Key Events

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Title Short name
Decreased, Synthesis of NE Decreased, Synthesis of NE
Decreased, GnRH cfos activity Decreased, GnRH cfos activity
Decreased, GnRH pulsatility/release Decreased, GnRH pulsatility/release
Decreased, LH Surge Decreased, LH Surge
Delayed, Ovulation Delayed, Ovulation
Decreased, Cortical granule release/distribution upon fertilization Decreased, Cortical granule release/distribution upon fertilization
Altered, Formation of cortical envelope Altered, Formation of cortical envelope
Abnormal, Sperm penetration (polyspermy) Abnormal, Sperm penetration (polyspermy)
Altered, Chromosome number (polyploid) zygote Altered, Chromosome number (polyploid) zygote

Adverse Outcome

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Title Short name
Decreased, Decreased fecundity Decreased, Decreased fecundity

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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